Department of Internal Diseases, Hypertension and Angiology The Medical University of Warsaw PHAEOCHROMOCYTOMA- Do classical symptoms help in diagnosis? Dorota Kwapisz, Marta Trafalska
PHAEOCHROMOCYTOMA Phaeochromocytomas are catecholamine- producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal paraganglia It`s rare tumour with a highly variable clinical presentation
Pts with paroxysmal signs or symptoms suggestive of a pheo The classical triad: headache sweating palpitations …hypertension asymptomatic pts with an adrenal incidentaloma PHAEOCHROMOCYTOMA
PHAEOCHROMOCYTOMA Although the presence of the classical Although the presence of the classical triad of symptoms of pheo may lead to correct diagnosis, yet frequently diagnosis is establised during evaluation of incidentally discovered mass (incidentaloma)
THE AIM The aim of the study was: To asses clinical presentation of pheo in recent series of cases, To compare the pts. with pheo in whom the diagnostics was triggered by symptoms (S – ”Symptomatic”) with those in whom diagnostics began with incidental finding of adrenal mass (I – „Incidentaloma”)
DESIGN AND METHODS n= 43 with pheo mean age 47.4 ± 13.1 yrs M/F 22/21 n= 29 „symptomatic”, n= 14 „incidentaloma” n= 39 – pheo was located in the adrenals (1 bilateral – 1S) (1 bilateral – 1S) n= 4 – extraadrenal (1S/3I) n= 4 – extraadrenal (1S/3I)
DESIGN AND METHODS „S” SYMPTOMATIC „S” SYMPTOMATIC „I” INCIDENTALOMA „I” INCIDENTALOMA n (pts) n (pts) Mean age ± yrs ± yrs ± yrs ± yrs M/F 15/14 15/14 7/7 7/7 Malignant 1 1 MEN IIB 1 1
METHODS Incidence of the most typical symptoms of pheo Duration of hypertension Urine excretion of metanephrines and catecholamine
METHODS Automatic Blood Pressure Monitoring(ABP) SpaceLabs Mean, maximum, SD of 24SBP/24DBP Echocardiography Hewlett-Packard LVMI
RESULTS Symptom S+ I S+ I S I p SWEATING 77 % 77 % 90 % 90 % 50 % 50 %<0,022 Headache Arrhythmias Palpitations Anxiety Pallor Triad Hypertension Weight loss
SYMPTOMS S 1. Sweating - 90% 2. Palpitations – 86% 3. Headaches – 78% The triad – 52% The triad – 52% I 1. Headaches – 62% 2. Sweating – 50% 3. Anxiety – 36% The triad – 14%
RESULTS – the triad
ABP S + I S + I S I 24SBP/24DBP 132/80 ± 16/10 133/79 ± 17/10 131/83 ± 14/10 24HR 79 ± ± ± ± ± 12 24SBP/24DBP- day/max 173/107177/107166/108 24SBP/24DBP - night/max 155/ / / 96 Duration of 5,43 ± 6,26 5,51 5,28 hypertension (yrs) (g/m2) LVMI (g/m2)
Metanephrines - mean: S-3790,50 I- 3365,30 p< 0,042 S : 270,8 –23666 I : 1375 – 10729,2
RESULTS S+I S I S+I S I Uricacid (mg/dl) 8,03 ± 15,03 9,20 5,38 p< 0,00(0) p< 0,00(0) Urea (mg/dl) 40,78 ± 25,08 41,99 37,90 p< 0,038 p< 0,038 Creatinine (mg/dl) 4,49 ± 22,19 6,17 0,86 p< 0,00(0) p< 0,00(0)
CONCLUSIONS The incidence of classical symptoms may be lower than previously reported Pheochromocytoma may mimic essential hypertension Lack of sweating may be misleading and lead to wrong diagnosis