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Thank You This PowerPoint document contains the images that you requested. Copyright Notice All Online Service materials, including, without limitation, text, pictures, graphics and other files and the selection and arrangement thereof are copyrighted materials of Ovid or its licensors, all rights reserved. Except for the Authorized Use specified above, you may not copy, modify or distribute any of the Online Service materials. You may not "mirror" any material contained on this Online Service on any other server. Any unauthorized use of any material contained on this Online Service may violate copyright laws, trademark laws, the laws of privacy and publicity and communications regulations and statutes.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 2 Table 1 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23): , June 4, Table 1 Demographic and Baseline Clinical Characteristics and Drug Susceptibility of the Patients.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 3 Table 2 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23): , June 4, Table 2 Incidence of Adverse Events.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 4 Figure 1 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23): , June 4, Figure 1 Mean (+/-SD) Plasma Concentration-Time Profiles for TMC207 at Week 2 and Week 8. Dosing was selected to maintain plasma TMC207 concentrations above a target average steady-state plasma concentration of 600 ng per milliliter. T bars indicate standard deviations.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 5 Figure 2 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23): , June 4, Figure 2 The Proportion of Patients with Positive Sputum Cultures and Time to Conversion. Proportions of positive cultures were determined according to the mycobacteria growth indicator tube (MGIT) system.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 6 Figure 3 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23): , June 4, Figure 3 Median (+/-SD) Log10 Count of Colony-Forming Units (CFUs). Median (+/-SD) log10 CFU counts over time are shown in the subgroup of 22 patients who provided pooled-sputum samples.