2014 年 4 月研究生读书报告王凯硕士研究生临床检验诊断学. Seminars In Cancer Biology A review of the current understanding and clinical utility of miRNAs in esophageal cancer.

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2014 年 4 月研究生读书报告王凯硕士研究生临床检验诊断学

Seminars In Cancer Biology A review of the current understanding and clinical utility of miRNAs in esophageal cancer Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma Cancer Discovery

Four miRNAs (mi-R-25, -99a, -133a and - 133b) showed good potential as diagnostic markers and interestingly five (mi-R-21, -27b, -126, and -145) appeared to be useful both as diagnostic and prognostic/predictive markers.

Summary of studies looking at miRNA expression in tumor tissues and non-tumor tissues

Summary of miRNAs identified to have a role in determining prognosis

Summary of key miRNAs identified as having a potential role in the diagnosis and/or prognosis of oesophageal cancer

11 EAC 23 fresh- frozen primary tumors NOTCH1 TP53 C:G>G:CA:T>C:G Tumor Tissue EAC 12 ESCC

Find out the drive gene MicroRNAs matched with the drive gene Quantitative detection of the expression of the gene and microRNA Analyze the relationship between the expression of the gene and microRNAs Experimental verification