LT Alphacarcidol 0.5 μg/day Adefovir 10 mg/day Lamivudine 100 mg/day Entecavir 1 mg/day Hospitalization P (mg/dL) ALP (U/L) P ALP Bone pain Years after LTMonths after hospitalization mg/day Supplemental Digital Content 1 - Figure 1. Serum phosphate and alkaline phosphatase levels in the patients with hypophosphatemic osteomalacia before and after hospitalization. Figures A, B and C represent the clinical courses of Patients 1, 2 and 3, respectively. Filled circles with solid lines in the graphs show the levels of serum phosphate and open squares with broken lines show the levels of serum alkaline phosphatase. The striped boxes indicate periods of hospitalization for each patient. The gray zones in the graphs correspond to the normal serum phosphate level. Arrowheads show the time of liver transplantation (LT). Tacrolimus 2 mg/day Fig 1A

LT Alphacarcidol 0.5 μg/day Adefovir dipivoxil 10 mg/day Lamivudine 100 mg/day Bone pain Phosphate 1 mg/day P (mg/dL) ALP (U/L) Hospitalization Years after LTMonths after hospitalization mg/day 1.5 mg/day Supplemental Fig. 1B P ALP Tacrolimus 2 mg/day

LT Tacrolimus 2 mg/day P (mg/dL) ALP (U/L) Bone pain Prednisolone 5 mg/day Hospitalization Years after LTMonths after hospitalization Supplemental Fig. 1C P ALP Alphacarcidol 2 μg/day