Group A3 Presenters: Anastasia Christopher, Carol Rego, Sarah McNeil Technical Experts: Bonnie Chan, Herman Gill, Marisa Leung
Brief overview of Module 3 Background information and important definitions Anatomy of the brain Lateral Geniculate Nucleus ◦ Method ◦ Results Primary Visual Cortex ◦ Method ◦ Results Conclusion Anastasia Christopher
By: Charles Gilbert and Torsten Wiesel Anastasia Christopher
Receptive Field Size Cortical Topography Binocular Retinal Lesion Scotoma Anastasia Christopher
Is the locus of change in regards to sensory input located at the cortical level (Primary Visual Cortex) or at a prior stage in the sensory pathway (Lateral Geniculate Nucleus)? Anastasia Christopher
Immediately After Lesion2 Months After Lesion LGN Primary Visual Cortex Anastasia Christopher
Studied 2 cats and 1 monkey Topographical mapping of the LGN Multiple electrode penetrations across the LGN Two injections of retrograde tracers in V1 Carol Rego
Large silent area about 1mm in diameter Shift in RF position Carol Rego
Immediately After Lesion2 Months After Lesion LGN ________________ Large silent area Shift in RF position No evidence in plasticity observed Primary Visual Cortex ________________ Carol Rego
Studied 4 cats and 6 monkeys RF maps were made using vertical electrode penetration RF maps were made at the same sites before, immediately after, and 2 months after making the lesion Sarah McNeil
Immediately after: ◦ Inactivity in original sites ◦ 5X larger sites ◦ Centrifugal shift Sarah McNeil Before lesion Immediately after lesion
2 months after: ◦ RF field size shrunk ◦ 5˚ centrifugal shift in position ◦ Area of activity expanded beyond affected area Sarah McNeil Before Lesion 2 Months After Lesion
Initial shock Long term consolidation Sarah McNeil
Immediately After Lesion2 Months After Lesion LGN ________________ Large silent area Shift in RF position No evidence in plasticity observed Primary Visual Cortex 5X larger in RF sites Centrifugal shift >1 ˚ RF field size shrunk to several times the original size Area of activity expanded Centrifugal shift 5 ˚ Sarah McNeil
Anastasia Christopher Is the locus of change in regards to sensory input located at the cortical level (Primary Visual Cortex) or at a prior stage in the sensory pathway (Lateral Geniculate Nucleus)?
Brain is high in plasticity Compensation of damaged tissue as a result of binocular retinal lesions does not take place in LGN Takes place at the cortical level of V1 Anastasia Christopher