of Cranberry seed extract together with Benefits of Taking AstaCran® The POWER of Cranberry seed extract together with the super-antioxidant AstaXanthin

Advantages of AstaCran® AstaCran® has extremely good stability NO harmful solvent residues Flaxseed and fish oils have a very short shelf life These oils actually become rancid in short time and can (in some cases) become carcinogenic No other supplement provides such a balanced ratio of essential fatty acids AstaCran ® is derived from highly-renewable and safe sources

Advantages of AstaCran® Source of balanced EFA’s Super Antioxidant Aids in maintaining cardiovascular health Aids with cholesterol management Protects skin and eyes from photic injury Reduce risk factors associated with macular degeneration “Anti-Aging” properties via reduction of oxidative stress Balanced EFA’s and super antioxidant in a single dose (Savings $$)

AstaCran® Cranberol™ Cranberry seed extract Zanthin™ Astaxanthin complex

Cranberries Vaccinium macrocarpon Cranberol™ Cranberry seed extract Cranberry seeds Supercritical CO2 extraction method NO harmful solvent residues High amounts of Essential Fatty Acids (EFA’s) Omega-3 and Omega-6 Also possesses antioxidants High levels of Phytosterols Cranberries Vaccinium macrocarpon

Cranberry Seed Extract Super Critical CO2 extraction Extraction performed under high pressure using CO2 as a solvent When extraction is complete, CO2 gas leaves NO residue (This may not be true with other commonly used solvents) This is an exception, not the standard Highly sustainable source of a balanced ratio of Essential Fatty Acids (EFAs)

Essential Fatty Acids Polyunsaturated Fatty Acids (PUFAs) “double bond” Omega-3 and Omega-6 Essential because your body does not produce them. Acquired from diet or food supplements Nutritionists have found that a balanced Omega-6/Omega-3 ratio of 1:1 is best for optimal health

EFA’s – Omega-6 & Omega-3 The current western diet: 15:1 and higher ratio Recommended dietary ratio: Between 5:1 and 10:1 1:1 ratio in humans is ideal The best supplemental source should have as close to a 1:1 ratio as possible

Omega-6 Linoleic acid (LA) Most commonly produced Essential This converts in the body to gamma-Linolenic acid (GLA) and then to prostaglandins that help regulate inflammation and blood pressure, as well as heart functioning. Linoleic acid (LA) Most commonly produced Essential Fatty Acid in agricultural seed oil production Majority intake from vegetable oils Highly unbalanced amounts of LA are bad because they promote inflammation, which can lead to many health problems Primarily beneficial when in balance with Omega-3’s Alpha-Linoleic Acids (ALAs)

Omega-3 ά Linolenic acid (ALA) High concentrations of Omega-3 improves vitality of the skin Absorption is enhanced when combined with Omega-6 As our diets have changed, Omega-3 consumption has decreased to a ratio that is associated with degenerative conditions Omega-3 helps reduce LDL cholesterol

Other Sources Other EFA sources Fish and shellfish Flaxseed (linseed) Canola oil, hemp oil, soya oil Chia seeds, pumpkin seeds, sunflower seeds Leafy vegetables and walnuts AstaCran can replace ALL other supplemental EFA sources (BIG savings)

Cranberol™ Antioxidants Tocopherols Vitamin E family Powerful antioxidant Tocotrienols Also a form of Vitamin E 40-60x stronger than tocopherols as an antioxidant

What is an Antioxidant? An·ti·ox·i·dant A substance (as beta-carotene or vitamin C) that inhibits oxidation or reactions promoted by oxygen, peroxides, or free radicals. Merriam-Webster Online It gives, takes, or traps an electron.

Phytosterols Phytosterols play an important role in maintaining a healthy cholesterol level Reduces cholesterol absorption in the intestines Similar chemical structures that compete with cholesterol for absorption. Significant for cardiovascular health Beta-sitosterol Helps reduce blood levels of cholesterol Stigmasterol

Cholesterol Low Density Lipoproteins (LDL) So called “Bad” cholesterol. Transports cholesterol into the arteries. High Density Lipoproteins (HDL) So called “Good” cholesterol Suspected to carry cholesterol from within* arteries to liver for redistribution or expulsion *ath·er·o·ma - 1:  Fatty degeneration of the inner coat of the arteries 2:  An abnormal fatty deposit in an artery Merriam-Webster Online

Cranberol™ Cranberol can aid and support a healthy cardiovascular system Aid in maintaining healthy cholesterol levels Aid in reduction of oxidative stress Desirable source for a balanced ratio of EFA’s Doesn’t turn rancid like many other sources of EFA’s

Zanthin® Astaxanthin complex Super-antioxidant Prevents oxidative damage 418g Atlantic Salmon = 3mg of astaxanthin. (1 pound = 453.59237 grams) Fish is becoming less desirable as a source for necessary compounds due to a concern over the rising levels of mercury, and various other heavy metals.

Source of Zanthin® Haematococcus microalgae Haematococcus pluvialis Unicellular green algae Found in Freshwater bodies SPECIES (3S,3’S) (3R,3’R) & (3R,3’S) (3R,3’R) Yeast (Phaffia sp.) --- <2% >98% Micro algae (Haematococcus) 100% Synthetic Astaxanthin (Carophyll Pink La Roche) 25% 50% Atlantic Salmon 78-85% 2-6% 12-17%(Schiedt et al 1981)cited in Foss 1984 Distribution of Astaxanthin stereo isomers in selected organisms (Bjerkeng1997)

Haematococcus Pluvialis Potent source of astaxanthin Highly renewable Safe Grown in a controlled environment

Other Sources Abundant in Nature (in water) Found in Salmon, Trout, Crustaceans, Crawfish,Pacific Cod, Scallops, Mackerel, Flounder, and other commercial seafood Renewable

Astaxanthin Concentration Species Amount of Astaxanthin present per Kilogram Atlantic Salmon 3 - 11mg Sockeye Salmon 26 - 37mg Rainbow Trout 1 - 13mg Yeast (Phaffia sp.) 30 - 800mg Algae (Haematococcus pluvialis) 10,000 - 30,000mg

Zanthin® Astaxanthin Super-antioxidant Properties of Astaxanthin Decreased DNA damage. Arrests mitochondrial free radicals Powerful Antioxidant Crosses blood-retina barrier Immune-modulatory activity Provides anti-inflammatory activity Increases strength and endurance Protects eyes and skin from photic injury

ORAC – Oxygen Radical Absorbance Capacity Antioxidant Studies ORAC – Oxygen Radical Absorbance Capacity AstaZanthin™ Standardized Extract Natural Lycopene Synthetic Astaxanthin Natural alpha-tocopherol Natural a-b Carotene mix Natural Tocotrienols Natural Lutein Natural Beta Carotene 1.380 0.596 0.419 0.381 0.345 0.318 0.280 0.242 Anti Oxidant Studies Naguib, Y., "Antioxidant Activities of Astaxanthin and Related Carotenoids,"Journal of Agricultural and Chemistry, v.48 (4), pp. 1150-1154.

Astaxanthin Astaxanthin was 10 - 50 times stronger than vitamin E in the lipid peroxidation of mitochondria membranes using the TBA method Inoue (1990) Astaxanthin is 10 times stronger than zeaxanthin, lutein, beta-carotene and canthaxanthin Astaxanthin is 100 times greater than alpha-tocopherol against active oxygen species in the thiobarbituric assay Miki (1991)

Strength and Endurance Fitness (submaximum load – Astrand method) Strength/Explosivity (Wingate method of maximum effort) Endurance (knee-bending technique) Malmsted, C.L. Gustavsberg, Sweden 6 Month Treatment Pre-treatment standardized exercise tests/endurance (p<0.05) Significant Improvement in strength/endurance (p<0.05) “Dietary Supplement with Astaxanthin-Rich Algal Meal Improves Muscle Endurance - A Double-blind Study on Male Students” N=40

Strength and Endurance Increased Carotenoid content