Fructose

FRUKTOSE (LEVULOSE) Blood Diabetes mellitus Glucose Galactose Fructose Food Honey Fruits Potato Onion + glucose + sucrose Degradation of sucrose Diabetes mellitus Influence on lipid metabolism

Effect of fructose Ingestion results in Chelating effect Obesity [LDL] á [TRIGLYCERID] á Metabolic syndroms Chelating effect Cu Zn Cr Insulin resistence (DM Type II. típus) Glycation of proteins

FRUCTOSE

Absorption of monosaccharides Transporters: GLUT-5 GLUT-2 Glucose

Absorption of carbohydrates 2Na+ Lactose Lactase Gal K+ Na+ ATP SGLT1 K+Na+ATP-ase Starch Amylase a-glucosidase Glu ADP K+ Sucrose Sucrase Fru GluT5 GluT2 Intestinalis lumen Entherocytes Extracellular space

GLUCOSE FRUCTOSE

D-fructose in liquor and in seminal plasma Peripherial neurons. Diabetic hyperglycaemia Accumulation of Sorbitol à periferial neuropathy

Degradation of fructose in muscle liver

Formation of methylglyoxal

Catabolism of methylglyoxal

Deficiency of liver fructokinase Benign disease Fructoseuria

FRUCTOSE GLUCOSE FRUCTOSE

Deficiency of Fructose-1-phosphate aldolase (Fructose intolerance) Hereditery fructose intolerance (HFI) fruktosemy Deficiency of fructose 1,6-bisphosphate aldolase B Def, of aldolase B vomiting hypoglycaemia Cachexy hepatomegaly jaundice coagulopathy Metabolic acidosis Coma renal Fanconi syndrome

GLUCOSE FRUCTOSE

Figure 1 Fructose-induced production of uric acid in the hepatocyte Nakagawa T et al. (2005) Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome Nat Clin Pract Neprol 1: 80–86 doi:10.1038/ncpneph0019

Foszfát-hiány [Fruktóz-1-P] á GLUKÓZ FRUKTÓZ A hipoglikémia kialakulásának valószínű oka

GLUKÓZ FRUKTÓZ