Preliminary observations on whole-ovary xenotransplantation as an experimental model for fertility preservation Stephanie M. Nichols-Burns, Laura Lotz,

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Presentation transcript:

Preliminary observations on whole-ovary xenotransplantation as an experimental model for fertility preservation Stephanie M. Nichols-Burns, Laura Lotz, Heike Schneider, Edyta Adamek, Christoph Daniel, Andrea Stief, Christina Grigo, Dorothee Klump, Inge Hoffmann, Matthias W. Beckmann, Ralf Dittrich Reproductive BioMedicine Online Volume 29, Issue 5, Pages 621-626 (November 2014) DOI: 10.1016/j.rbmo.2014.07.017 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Placement of the retransplanted swine ovary with sutures (arrows) within the nude rat recipient. Reproductive BioMedicine Online 2014 29, 621-626DOI: (10.1016/j.rbmo.2014.07.017) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Representative histological sections illustrating the appearance of fresh control ovaries (A) and transplanted ovaries (B,C). Retained ovarian stromal structure, intact blood vessels and follicles from primordial to antral developmental stages were evident in the surviving transplanted ovaries (B, 4-week old transplant); fibrotic stromal tissue, the presence of inflammatory cells and damaged, absent follicles, or both, were evident in the failed transplants (C) (n = 4). Scale bar = 100 µm. Reproductive BioMedicine Online 2014 29, 621-626DOI: (10.1016/j.rbmo.2014.07.017) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions