Regulation of serum calcium homeostasis.

Slides:

Advertisements

Similar presentations

بسم الله الرحمن الرحيم.

Advertisements

Ca++ absorbed into blood

Hyperparathyroidism in Chronic Kidney Disease 醫五李政霆.

Homeostatic Regulation of Blood Calcium and Blood Glucose.

CALCIUM AND PHOSPHATE HOMEOSTASIS. Organs: Parathyroid Four oval masses on posterior of thyroid gland Develops from the 3 rd and 4 th pharyngeal pouches.

PARATHYROID BY ALLYRILEY & CODYPRICE PERIOD 7. WHERE The parathyroid is located in the neck. Located behind the thyroid gland Everyone has four parathyroid.

VIII. Calcium Homeostasis A. Bone Composition 1. Contains x’s more calcium than all other tissues combined 2. In blood level of Ca is monitored.

PTH Calcitonin 10mg% Vitamin D Lecture 52 Ca++ Homeostasis

Luke Laney and Joy Bartolotta Bertsch 6B

Calcium & Phosphate Metabolism Calcium homeostasis Calcium in blood & cells  or  Ca 2+ — consequences: short term long term Roles of gut, bone, kidney.

Control of Blood Ca. Why is Calcium important? Ca is essential for healthy teeth and skeletal development It is also involved in: Blood clotting (Ca.

MLAB 2401: Clinical Chemistry Keri Brophy-Martinez

Parathyroid hormone(Parathormone) Lecture NO: 2nd MBBS

MLAB 2401: Clinical Chemistry Keri Brophy-Martinez

Calcitonin Calcitonin By: Narjes lavasani.

Hormones that affect metabolism: Thyroid Gland

About 10% of bone is replaced every year in an adult skeleton

Volume 79, Pages S3-S8 (April 2011)

Vitamin D3 Presented by John Lear.

Parathyroid Hormone By Ezinne Akudinobi.

Responses to reduced plasma calcium concentration

Effects of active metabolites of vitamin D (D), parathyroid hormone (PTH), calcitonin (CT), and fibroblast growth factor 23 (FGF23) on calcium and phosphorus.

The Endocrine System Thyroid & Parathyroid

Negative feedback regulation of parathyroid hormone (PTH) release

Vitamin D metabolism and physiologic effects at target organs

Figure 1 Disruption of phosphate homeostasis in chronic kidney disease (CKD) Figure 1 | Disruption of phosphate homeostasis in chronic kidney disease (CKD).

High Prevalence of Vitamin D Inadequacy and Implications for Health

Calcitonin By Mollie Rubinstein.

Volume 73, Issue 1, Pages 3-5 (January 2008)

The Gutsy Side of Bone Cell Metabolism

Fibroblast Growth Factor 23 and CKD Prognosis

Renal vitamin D receptor expression and vitamin D renoprotection

Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis

High Prevalence of Vitamin D Inadequacy and Implications for Health

Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease Adriana S. Dusso,

FGF23 or PTH: which comes first in CKD ?

FGF23–parathyroid interaction: implications in chronic kidney disease

Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets David M. Spiegel, Kate Brady Kidney.

The major function of the parathyroid glands is to maintain the body's calcium level within a very narrow range, so that the nervous and muscular systems.

Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation Adriana S. Dusso Kidney International Supplements

Volume 79, Pages S3-S8 (April 2011)

Parathyroid hormone(Parathormone) Lecture NO: 2nd MBBS

Animal Form & Function Homeostasis

Volume 60, Issue 4, Pages (October 2001)

Volume 60, Issue 5, Pages (November 2001)

Volume 79, Pages S20-S23 (April 2011)

Volume 75, Issue 11, Pages (June 2009)

Vitamin D receptor: A highly versatile nuclear receptor

Parathyroid hormone (PTH) levels by Dialysis Outcomes and Practice Patterns Study (DOPPS) phase and selected patient characteristics. Parathyroid hormone.

Volume 87, Issue 3, Pages (March 2015)

Volume 58, Issue 4, Pages (October 2000)

Volume 85, Issue 6, Pages (June 2014)

Volume 75, Issue 9, Pages (May 2009)

Volume 78, Issue 4, Pages (August 2010)

Fibroblast growth factor 23: the making of a hormone

Peripheral Glands.

Phosphate and the parathyroid

Latest findings in phosphate homeostasis

Volume 71, Issue 8, Pages (April 2007)

Pablo A. Ureña Torres, Marc De Broe Kidney International

Mineral metabolism in CKD: adaptation devolves into maladaptation.

Recent developments in the management of secondary hyperparathyroidism

Increased fetuin-A levels following treatment with a vitamin D analog

The ins and outs of phosphate homeostasis

Diagram of the mechanisms involved in limiting the ability of the kidney to maintain the levels of 1,25-dihydroxyvitamin D in chronic kidney disease (CKD).

Marta Christov, Harald Jüppner Kidney International

Attributable risk for disorders of mineral metabolism.

Parathyroid hormone (PTH) -fibroblast growth factor 23 (FGF23) feedback loop. Parathyroid hormone (PTH) -fibroblast growth factor 23 (FGF23) feedback loop.

Volume 64, Pages S131-S136 (November 2003)

Untangling Klotho's Role in Calcium Homeostasis

Presentation transcript:

Regulation of serum calcium homeostasis. Regulation of serum calcium homeostasis. Serum calcium homeostasis is regulated by a rapid negative feedback hormonal pathway involving the concentration of ionized calcium in serum (Ca, green arrows) and the secretion of parathyroid hormone (PTH, blue arrows) from the parathyroid. A fall in serum calcium (↓ Ca) inactivates the calcium receptor in the parathyroid cell (CaR; green circle) and increases PTH secretion (↑ PTH), which restores serum calcium (↑ Ca) by activating the parathyroid receptor (PTHR; blue circles) in bone, to increase calcium resorption, and in kidney, to increase tubular calcium reabsorption. In kidney, the increased PTH secretion augments its calcium-restorative effect by increasing secretion of 1,25-dihydroxyvitamin D (1,25D; red arrows), which, acting on the vitamin D receptor (VDR, red circles) in gut, increases active calcium absorption and increases calcium resorption in bone. Munro Peacock CJASN 2010;5:S23-S30 ©2010 by American Society of Nephrology