1. Negative feedback regulation of parathyroid hormone (PTH) release
Negative feedback regulation of parathyroid hormone (PTH) release. A sudden decrease in Ca2+ stimulates the release of PTH from the parathyroid gland. PTH increases the activity of 1α-hydroxylase in the kidney, leading to increased activation of vitamin D. In addition, PTH increases the reabsorption of Ca2+ and decreases the reabsorption of inorganic phosphate (Pi). In bone, PTH stimulates bone resorption, increasing the plasma Ca2+ levels. The elevations in vitamin D and plasma Ca2+ levels exert negative feedback inhibition of PTH release. Elevations in plasma Pi levels stimulate the release of PTH.
Source: Chapter 5. Parathyroid Gland and Ca2+ and PO4- Regulation, Endocrine Physiology, 4e
Citation: Molina PE. Endocrine Physiology, 4e; 2013 Available at: Accessed: December 17, 2017
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