Genomewide Comparison of DNA Sequences between Humans and Chimpanzees

Slides:



Advertisements
Similar presentations
Genomewide Linkage Analysis of Bipolar Disorder by Use of a High-Density Single- Nucleotide–Polymorphism (SNP) Genotyping Assay: A Comparison with Microsatellite.
Advertisements

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants Martin F. Arlt, Jennifer G.
Nuclear and Mitochondrial DNA Analysis of a 2,000-Year-Old Necropolis in the Egyin Gol Valley of Mongolia Christine Keyser-Tracqui, Eric Crubézy, Bertrand.
Length Distributions of Identity by Descent Reveal Fine-Scale Demographic History Pier Francesco Palamara, Todd Lencz, Ariel Darvasi, Itsik Pe’er The American.
Elevated Frequency and Allelic Heterogeneity of Congenital Nephrotic Syndrome, Finnish Type, in the Old Order Mennonites Stacey Bolk, Erik G. Puffenberger,
Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.
The Novel Genetic Disorder Microhydranencephaly Maps to Chromosome 16p  
Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
A Multilocus Model of the Genetic Architecture of Autoimmune Thyroid Disorder, with Clinical Implications Veronica J. Vieland, Yungui Huang, Christopher.
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.
Fragile X and X-Linked Intellectual Disability: Four Decades of Discovery Herbert A. Lubs, Roger E. Stevenson, Charles E. Schwartz The American Journal.
Nonresonant Confocal Raman Imaging of DNA and Protein Distribution in Apoptotic Cells N. Uzunbajakava, A. Lenferink, Y. Kraan, E. Volokhina, G. Vrensen,
The Duty to Recontact: Attitudes of Genetics Service Providers Jennifer L. Fitzpatrick, Cecil Hahn, Teresa Costa, Marlene J. Huggins The American Journal.
PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent Jeffrey Staples, Dandi Qiao, Michael H. Cho, Edwin K. Silverman,
Peopling of Sahul: mtDNA Variation in Aboriginal Australian and Papua New Guinean Populations Alan J. Redd, Mark Stoneking The American Journal of Human.
Enterococcus faecalis Induces Inflammatory Bowel Disease in Interleukin-10 Knockout Mice Edward Balish, Thomas Warner The American Journal of Pathology.
Anna Middleton, J. Hewison, R.F. Mueller 
Transmission/Disequilibrium Tests for Extended Marker Haplotypes
Genetic Landscape of Eurasia and “Admixture” in Uyghurs
Anna Middleton, J. Hewison, R.F. Mueller 
Jacek Majewski  The American Journal of Human Genetics 
Human Diallelic Insertion/Deletion Polymorphisms
Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs  Jian Huang, Yanming Jiang  The.
CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies 
2016 Curt Stern Award Address: From Rare to Common Diseases: Translating Genetic Discovery to Therapy1  Brendan Lee  The American Journal of Human Genetics 
Yu Jiang, Glen A. Satten, Yujun Han, Michael P. Epstein, Erin L
A Combined Linkage-Physical Map of the Human Genome
Genetics, Individuality, and Medicine in the 21st Century*
The American Journal of Human Genetics 
Salt and Hypertension American Journal of Kidney Diseases
XMCPDT Does Have Correct Type I Error Rates
A Chromosomal Duplication Map of Malformations: Regions of Suspected Haplo- and Triplolethality—and Tolerance of Segmental Aneuploidy—in Humans  Carole.
GeneTests: Integrating Genetic Services into Patient Care*
Variant Association Tools for Quality Control and Analysis of Large-Scale Sequence and Genotyping Array Data  Gao T. Wang, Bo Peng, Suzanne M. Leal  The.
Deamination Effects in Formalin-Fixed, Paraffin-Embedded Tissue Samples in the Era of Precision Medicine  Seokhwi Kim, Charny Park, Yongick Ji, Deok G.
Chapter 2 Demographics Journal of Obstetrics and Gynaecology Canada
Family-Based Association Studies for Next-Generation Sequencing
E. Warwick Daw, Simon C. Heath, Ellen M. Wijsman 
The SNP Endgame: A Multidisciplinary Approach*
Family-Based Tests of Association in the Presence of Linkage
Erratum The American Journal of Human Genetics
Evidence for Variable Selective Pressures at MC1R
A Comprehensive Survey of Human Y-Chromosomal Microsatellites
Michael P. Epstein, Xihong Lin, Michael Boehnke 
Journal of Investigative Dermatology 
Volume 69, Issue 12, Pages (June 2006)
Volume 69, Issue 3, Pages (February 2006)
Increasing the Power and Efficiency of Disease-Marker Case-Control Association Studies through Use of Allele-Sharing Information  Tasha E. Fingerlin,
Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements  Beatrice Schmucker, Michael Krawczak 
Greg L. Loeben, Theresa M. Marteau, Benjamin S. Wilfond 
Jared R. Kohler, David J. Cutler 
Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo 
Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications 
News & Notes Journal of Allergy and Clinical Immunology
Psoriasis Genetics: The Way Forward
Discussion The Journal of Thoracic and Cardiovascular Surgery
Identification of Genetic Markers Associated with Gilles de la Tourette Syndrome in an Afrikaner Population  Ingrid Simonic, George S. Gericke, Jurg Ott,
Efficient Computation of Significance Levels for Multiple Associations in Large Studies of Correlated Data, Including Genomewide Association Studies 
Volume 2, Issue 6, Pages (June 2017)
On the Etruscan Mitochondrial DNA Contribution to Modern Humans
Alice S. Whittemore, Jerry Halpern 
Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs  Jian Huang, Yanming Jiang  The.
Anna Middleton, J. Hewison, R.F. Mueller 
Zuoheng Wang, Mary Sara McPeek  The American Journal of Human Genetics 
A Chromosomal Deletion Map of Human Malformations
Passorn Wonnapinij, Patrick F. Chinnery, David C. Samuels 
The Size Distribution of Homozygous Segments in the Human Genome
Presentation transcript:

Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo  The American Journal of Human Genetics  Volume 70, Issue 6, Pages 1490-1497 (June 2002) DOI: 10.1086/340787 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Histogram showing the number of DNA sequence positions compared per human chromosome The American Journal of Human Genetics 2002 70, 1490-1497DOI: (10.1086/340787) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 Mean DNA sequence differences between humans and chimpanzees by human chromosome. Bars indicate 95% CIs. The American Journal of Human Genetics 2002 70, 1490-1497DOI: (10.1086/340787) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 3 Frequency distribution of DNA sequence differences between chimpanzees and humans, for each human chromosome. Ti = transitions. The American Journal of Human Genetics 2002 70, 1490-1497DOI: (10.1086/340787) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 4 Genomewide average frequencies for various nucleotide differences between chimpanzees and humans (A) and among humans (B). Ti = transitions. The American Journal of Human Genetics 2002 70, 1490-1497DOI: (10.1086/340787) Copyright © 2002 The American Society of Human Genetics Terms and Conditions