Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across 22 cancer types. Heatmap of Spearman's correlation coefficients calculated from the comparison of the T-cell marker CD3D (A) or the B-cell marker CD20 (B) with the indicated APOBEC family member. Expression levels were determined using TCGA RNAseq data (see Supplementary Table S3 for the long form for each tumor abbreviation). Dark red squares indicate strong positive correlations, dark blue squares indicate strong negative correlations, and white squares indicate a lack of correlation. Brandon Leonard et al. Clin Cancer Res 2016;22:4746-4755 ©2016 by American Association for Cancer Research