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Distribution of FGFR aberrancies in urothelial cancers.

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Presentation on theme: "Distribution of FGFR aberrancies in urothelial cancers."— Presentation transcript:

1 Distribution of FGFR aberrancies in urothelial cancers.
Distribution of FGFR aberrancies in urothelial cancers. Cancers included urothelial carcinomas (transitional cell carcinomas) of the bladder, renal pelvis, ureter, and not specified. The majority of aberrations were activating mutations in FGFR3, including S249C (8 instances), R248C (6 instances), Y373C (2 instances), G370C (2 instances), and K650M (1 instance). Three of these FGFR3 mutations are also about to transform cells in vitro (S249C, S248C, Y737C; Supplementary Table S4). Frequencies are expressed as percentages of all 126 cases. There were 44 aberrations in 40 cases (4 cases had more than one aberration), so the total is greater than 100%. Teresa Helsten et al. Clin Cancer Res 2016;22: ©2016 by American Association for Cancer Research

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