International Vision Correction Research Centre E-mail:angela.ehmer@med.uni-heidelbergd.de www.lasik-uni-hd.de Evaluation of phakic irisfixated intraocular lenses with Zeiss Visante OCT A. Ehmer, C. Foerster, M.P. Holzer, G.U. Auffarth Dept. of Ophthalmology Ruprecht-Karls-University Heidelberg Acting-chairman: G. U. Auffarth, MD The authors have no financial interests in any of the products mentioned.

Purpose, Methods & Patients Visualisation and detection of lens position of phakic intraocular lenses in the anterior chamber of the human eye. Methods Phakic irisfixated IOLs (Verisyse, AMO) were implanted to correct ametropia (Figure 1) Lens position in the anterior chamber was measured with Zeiss Visante OCT (Figure 2) ACD was measured with Zeiss IOL Master (Figure 3) and Oculus Pentacam HR (Figure 4) Data were collected 4 to 26 months postoperatively Patients 24 eyes of 12 patients, mean age of 38.1 ± 5.9 years 76 eyes of healthy patients from refractive polyclinic were enrolled in this retrospective data analysis. Mean age was 36.6 +/- 8.2 years, there were 48 female and 28 male patients. Figure 1 Figure 2 Figure 3 Figure 4 Angela Ehmer, MSc

Results I Figure 5 shows the pIOL in the anterior chamber. The distance from pIOL to corneal endothelium magnified in Figure 6 and pIOL to cristalline lens in Figure 7. Figure 7 Figure 6 Distance cornea – pIOL in mm ACD preop in mm Figure 5 A high correlation between the preoperative anterior chamber depth and the distance of the phakic IOL to corneal endothelium (r = 0.83) was found (figure 8). The deeper the anterior chamber the greater the distance between cornea and phakic IOL. Here you can see the box plots of our data. The left one shows the data of Procyon pupil sizes. There were significant differences between the illumination profiles. On the right side you see the range of pupil sizes measured with with the topographic and wavefrontanalysing devices. There are also significant differences in all devices tested. Figure 8 Angela Ehmer, MSc

Results II Figure 10 Figure 9 The mean distance between the phakic IOL and the endothelium of the cornea was 2.21 ± 0.31 mm (figure 9) The mean distance between the natural crystalline lens to the phakic IOL was 0.80 ± 0.18 mm (figure 10) High correlation was found between target refraction and refraction three months postoperatively (R = 0.98) (figure11) Here you can see the box plots of our data. The left one shows the data of Procyon pupil sizes. There were significant differences between the illumination profiles. On the right side you see the range of pupil sizes measured with with the topographic and wavefrontanalysing devices. There are also significant differences in all devices tested. Figure 11 Angela Ehmer, MSc

Conclusion The Zeiss Visante OCT is suitable to demonstrate IOL position in the anterior chamber of the eye. The data analysed showed a confident implantation without impairing the corneal endothelium over a 26 months follow up period. Literatur Konstantopoulos A, Hossain P, Anderson DF. Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis? Br J Ophthalmol. 2007 Apr;91(4):551-7. Review. Lavanya R, Teo L, Friedman DS, Aung HT, Baskaran M, Gao H, Alfred T, Seah SK, Kashiwagi K, Foster PJ, Aung T: Comparison of anterior chamber depth measurements using the IOLMaster, Scanning Peripheral Anterior Chamber depth Analyser and Anterior Segment Optical Coherence Tomography. Br J Ophthalmol. 2007 Feb 27; Rabsilber TM, Khoramnia R, Auffarth GU. Anterior chamber measurements using Pentacam rotating Scheimpflug camera.J Cataract Refract Surg. 2006 Mar;32(3):456-9. Wang L, Auffarth GU. White-to-white corneal diameter measurements using the eyemetrics program of the Orbscan topography system. Dev Ophthalmol. 2002;34:141-6. It is possible to measure pupil size with multifuncional devices however its important to know Angela Ehmer, MSc