Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.

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Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. To determine whether immunization with CT α-syn antibodies rescued the loss of TH fibers in α-syn tg mice, brain sections of non-tg mice immunized with 27-1 or α-syn tg mice immunized with 27-1, 9E4, 1H7, 5C1, or 5D12 were immunostained with an antibody against TH. A, Representative images of the substantia nigra and the striatum of non-tg mice immunized with 27-1 or α-syn tg mice immunized with 27-1, 9E4, 1H7, 5C1, or 5D12 immunostained with an antibody against TH. Scale bar, 50 μm. B, Cell counts of TH-immunoreactive neurons in substantia nigra. C, Optical density analysis of TH immunoreactivity in striatum. D, To determine whether immunization with CT α-syn antibodies reduced neuroinflammation in α-syn tg mice, brain sections of non-tg mice immunized with 27-1 or α-syn tg mice immunized with 27-1, 9E4, 1H7, 5C1, or 5D12 were immunostained with an antibody against GFAP (astrocytes) or Iba1 (microglia). Representative images of the striatum are shown. Scale bar, 250 μm. E, Cell counts of GFAP-immunoreactive cells in striatum. F, Cell counts of Iba1-immunoreactive cells in striatum. Error bars represent ± SEM. **p < 0.01 and ***p < 0.001 comparing non-tg 27-1-immunized mice with α-syn tg 27-1-immunized mice; #p < 0.05, ##p < 0.01, ###p < 0.001 comparing α-syn tg mice immunized with 27-1 with α-syn tg mice immunized with 9E4, 1H7, or 5C1. Dora Games et al. J. Neurosci. 2014;34:9441-9454 ©2014 by Society for Neuroscience