Effects of ASGR2 knockdown on the phenotypes of MKN1 cells.

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Effects of ASGR2 knockdown on the phenotypes of MKN1 cells. Effects of ASGR2 knockdown on the phenotypes of MKN1 cells. A, Inhibitory effect of the knockdown of ASGR2 mRNA and (B) protein expression. C, The proliferation of cells transfected with siASGR2 was lower than that of untransfected and siControl cells according to the WST-8 assay. D, Cell counts of cells that invaded the Matrigel chamber were reduced in cells transfected with siASGR2. E, Cell adherence to matrices was reduced by siASGR2, particularly fibronectin, collagen I, and collagen IV. F, siASGR2 inhibited cell migration across the cell wound gap. G, However, siASGR2 did not appear to induce apoptosis. *, significant difference (P < 0.05). Haruyoshi Tanaka et al. Mol Cancer Res 2018;16:1420-1429 ©2018 by American Association for Cancer Research