Gametocytes as an early indicator of parasite resistance.

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Gametocytes as an early indicator of parasite resistance. Gametocytes as an early indicator of parasite resistance. The data presented are from a study in the Gambia where children were treated with chloroquine (184). The figure presents gametocyte prevalence by microscopy (thick blood films; screening of 100 high-power fields at a magnification of ×1,000, using oil immersion) on day 7 after treatment (left y axis; error bars indicate the upper limit of the 95% confidence interval), median gametocyte density by microscopy in gametocyte carriers on day 7 after treatment (right y axis; error bars indicate the upper limit of the interquartile range), and the mean proportion of infected mosquitoes determined by membrane feeding assays (right y axis; error bars indicate the upper limit of the 95% confidence interval). Wild type, no mutations detected at enrollment in two genes related to chloroquine resistance, P. falciparum multidrug resistance gene 1 (Pfmdr1 86Y) and P. falciparum chloroquine resistance transporter (Pfcrt 76T); single mutant, mutation detected in either Pfmdr1 or Pfcrt; double mutant, mutation detected in both Pfmdr1 and Pfcrt. Teun Bousema, and Chris Drakeley Clin. Microbiol. Rev. 2011; doi:10.1128/CMR.00051-10