1. Titration of antibiotic perturbations results in altered community structures and C. difficile colonization resistance.
Titration of antibiotic perturbations results in altered community structures and C. difficile colonization resistance. Bars indicate the median percent relative abundance of those selected OTUs from all treatment groups on the day of C. difficile challenge. Asterisks along the x axis indicate those OTUs that varied significantly across doses of the same antibiotic after correcting for multiple comparisons. The error bars indicate the interquartile range. The number of animals used in each treatment group is indicated in the legend, which also gives the dose of each antibiotic that was used. The median level C. difficile colonization found 24 h after microbiota sampling is plotted on the right for each treatment, with error bars indicating the interquartile range. Letters above colonization levels indicate statistical differences between groups. Values that are not significantly different (NS) are indicated.
Alyxandria M. Schubert et al. mBio 2015; doi: /mBio