Fig. 3. Generation of induced microglia like cells from peripheral blood mononuclear cells (A) and defected microglial phagocytosis in rapidly progressive.

Slides:



Advertisements
Similar presentations
Microglia are tissue-resident macrophages in the CNS.
Advertisements

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume.
INTRODUCTION TO THE IMMUNE SYSTEM
From: A Pilot Study of an Oral Phosphodiesterase Inhibitor (Apremilast) for Atopic Dermatitis in Adults Arch Dermatol. 2012;148(8): doi: /archdermatol
Inflamm Intest Dis 2016;1: DOI: /
Alzheimer's disease drug development pipeline: 2017
Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells.
MM McDermott and coauthors
Effects of a caspase-1 inhibitor and NLRP3 inhibitor on nontypeable Haemophilus influenzae (NTHi)-induced interleukin (IL)-1β production. a) Peripheral.
Interleukin (IL)-1β-producing cells in peripheral blood mononuclear cells (PBMCs). Interleukin (IL)-1β-producing cells in peripheral blood mononuclear.
Germaine Wong, Jeremy R. Chapman, Jonathan C. Craig 
Effect of interleukin-5 and granulocyte-macrophage colony stimulating factor on in vitro eosinophil function: Comparison with airway eosinophils  Julie.
by Xiaowu Zhang, and Ruibao Ren
Figure 1 Physiological metabolism of Aβ in the brain and periphery
Adam J. Byrne, Toby M. Maher, Clare M. Lloyd 
Covering the Cover Gastroenterology
Stefan H.E. Kaufmann, Shreemanta K. Parida  Cell Host & Microbe 
Extracorporeal Photopheresis and Adjuvant Aerosolized Granulocyte-Macrophage Colony-Stimulating Factor for Sézary Syndrome  Saskia A. Bouwhuis, MD, Svetomir.
The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: A protein array study  Rachel K. Middleton, BSc,
A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease  John.
Cytokines and Chemokines Chapter 6
Volume 151, Issue 4, Pages (October 2016)
Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase.
Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy  Stephanie K. Beidler, MD, Christelle D.
Immunotherapy of aspergillosis
Pg and Ec LPS induced levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Pg and Ec LPS induced levels.
Impact of Mobilization and Remobilization Strategies on Achieving Sufficient Stem Cell Yields for Autologous Transplantation  Iskra Pusic, Shi Yuan Jiang,
Volume 64, Issue 1, Pages (July 2003)
Amyloid Cascade into Clarity
L. Y. A. Chai, R. Naesens, A. L. Khoo, M. V. Abeele, K
Why is mucormycosis more difficult to cure than more common mycoses?
Volume 18, Issue 4, Pages (April 2010)
Genomic and proteomic determinants of lower extremity revascularization failure: Rationale and study design  Peter R. Nelson, MD, Kerri A. O’Malley, PhD,
Y. -P. Ding, M. -F. Liang, J. -b. Ye, Q. -h. Liu, C. -h. Xiong, B
F.L. van de Veerdonk, B.-J. Kullberg, M.G. Netea 
Figure 2 GM-CSF — a key player in inflammation and autoimmunity
Unstimulated levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Unstimulated levels of soluble mediators.
Macrophages and dendritic cells: what is the difference?
Long-term marrow reconstitutive ability of autologous grafts in lymphoma patients using peripheral blood mobilized with granulocyte colony-stimulating.
The landscape of cytokine-producing CD4 T cell populations in the peripheral blood (PB) and in the joints. Venn diagrams show the frequency of overlapping.
Holger Lawall, MD, Peter Bramlage, MD, PhD, Berthold Amann, MD 
Evolving characteristics of toxoplasmosis in patients infected with human immunodeficiency virus-1: clinical course and Toxoplasma gondii-specific immune.
Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease  Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,
TLR9 deficiency promotes aberrant T cell and myeloid dendritic cell (DC) phenotype in imiquimod-induced autoimmunity. TLR9 deficiency promotes aberrant.
Effect of anemia and renal cytokine production on erythropoietin production during blood-stage malaria  Kai-Hsin Chang, Mary M. Stevenson  Kidney International 
Volume 141, Issue 1, Pages (July 2011)
Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma  Mauricette Michallet, Thierry.
Stefan H.E. Kaufmann, Shreemanta K. Parida  Cell Host & Microbe 
6. Asthma Journal of Allergy and Clinical Immunology
Fig. 1 Differentiation of human peripheral blood monocytes into MDMi cells induces a microglial gene expression and functional phenotype. Differentiation.
Figure 2 Immune changes in peripheral blood of pregnant patients with NMO Immune changes in peripheral blood of pregnant patients with NMO (A) Interleukin.
David C. Soler, Thomas S. McCormick 
Measurement of a) IL-8, b) IL-6 and c) GM-CSF release by BEAS-2B cells stimulated with deoxycholic acid for 48 h. Measurement of a) IL-8, b) IL-6 and c)
Nat. Rev. Rheumatol. doi: /nrrheum
Lec.9 Cytokines.
Human granulocyte-macrophage colony-stimulating factor (hGM-CSF)–dependent in vitro and in vivo proliferation and differentiation of all hematopoietic.
Angiogenesis and arteriogenesis in limb ischemia
Decreased interleukin-18 expression in BAL cells and peripheral blood mononuclear cells in adult cystic fibrosis patients  Hans-Peter Hauber, Inga S Beyer,
Volume 66, Issue 2, Pages (August 2004)
Figure 4 Alemtuzumab-mediated effects on interleukin (IL)–23 and granulocyte-macrophage colony-stimulating factor (GM-CSF) production in innate myeloid.
Figure 1. MBP-specific IFN-γ+ but not IL-17+ frequencies are significantly different between patients with MS and HCs MBP-specific IFN-γ+ but not IL-17+
Figure 2 Effect of DMF therapy on the T helper cell repertoire and cytokine production Effect of DMF therapy on the T helper cell repertoire and cytokine.
Recombinant human thrombopoietin augments mobilization of peripheral blood progenitor cells for autologous transplantation  Charles Linker, Paolo Anderlini,
Interleukin-2 (IL-2) concentrations in phytohemagglutinin (PHA)-treated and untreated peripheral blood mononuclear cells in children with sickle cell disease.
Regulatory role of iNKT cells in T1D in humans and mice
Tim C. McQuinn, MD, Rachael L
Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass  Chung-Hsi Hsing, MD, Mei-Yi Hsieh, MS, Wei-Yu Chen,
Fig. 2. Scriptaid and RGFP966 alter macrophage phenotype
Fig. 1. ROC curve for K-IADL to diagnose dementia or MCI
Fig. 1 Differentiation of human peripheral blood monocytes into MDMi cells induces a microglial gene expression and functional phenotype. Differentiation.
Presentation transcript:

Fig. 3. Generation of induced microglia like cells from peripheral blood mononuclear cells (A) and defected microglial phagocytosis in rapidly progressive AD compared to early AD and normal controls (B). AD: Alzheimer's disease, GM-CSF: granulocyte-macrophage colony-stimulating factor, IL-34: interleukin-34, I-MG: induced microglia, HC: healthy controls, AD (E): Alzheimer's disease (early), AD (R): Alzheimer's disease (rapidly). Fig. 3. Generation of induced microglia like cells from peripheral blood mononuclear cells (A) and defected microglial phagocytosis in rapidly progressive AD compared to early AD and normal controls (B). AD: Alzheimer's disease, GM-CSF: granulocyte-macrophage colony-stimulating factor, IL-34: interleukin-34, I-MG: induced microglia, HC: healthy… Dement Neurocogn Disord. 2019 Jun;18(2):33-46. https://doi.org/10.12779/dnd.2019.18.2.33