European Society of Cardiology guidelines for the diagnosis of a) clinically suspected high-risk pulmonary embolism (PE) and b) clinically suspected non-high-risk PE. #: i.e. with shock and/or hypotension. ¶: not available if the patient's condition allows ... European Society of Cardiology guidelines for the diagnosis of a) clinically suspected high-risk pulmonary embolism (PE) and b) clinically suspected non-high-risk PE. #: i.e. with shock and/or hypotension. ¶: not available if the patient's condition allows bedside diagnostic tests only. +: transoesophageal echocardiography may detect pulmonary arterial thrombi in a significant proportion of patients with right ventricular (RV) overload and PE that is ultimately confirmed by spiral computed tomography (CT). Confirmation of deep vein thrombosis with bedside compression ultrasound could also assist decision-making. §: two alternative classification schemes may be used for clinical probability assessment; i.e. a three-level scheme (low, intermediate or high) or a two-level scheme (PE unlikely or PE likely). ƒ: e.g. Wells score. Adapted from [2] and [10]. Rachel Limbrey, and Luke Howard Eur Respir Rev 2015;24:484-497 ©2015 by European Respiratory Society