Molecular Recognition of Cargo by the COPII Complex

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Molecular Recognition of Cargo by the COPII Complex Charles Barlowe Cell Volume 114, Issue 4, Pages 395-397 (August 2003) DOI: 10.1016/S0092-8674(03)00650-0

Figure 1 Multiple Cargo Binding Sites in the Sec23/24-Sar1 Prebudding Complex Surface representation of the prebudding complex with the Sec23 subunit colored in green, Sec24 in yellow, and Sar1 in blue. Red highlights in Sec24 indicate positions of the YNNSNPF peptide sequence of Sed5 bound at the A-site, the LASLE peptide sequence of Bet1 bound at the B-site and arginine residue 342 (Arg342) that is required for Sec22 recognition. A characterized di-acidic export signal (DLESQ) also binds to the B-site of Sec24. (Figure kindly provided by J. Goldberg). Cell 2003 114, 395-397DOI: (10.1016/S0092-8674(03)00650-0)