NAFLD and NASH in Europe and Canada

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Presentation transcript:

NAFLD and NASH in Europe and Canada

NAFLD: Spectrum of Disease and Clinical Outcomes

The Changing Face of Liver Disease in Europe

NAFLD and Cardiometabolic Complications

Prevalence of NAFLD in Europe

Why Are NAFLD and NASH Under-Recorded?

Roles of Diabetes and Obesity in NAFLD

Prevalence of NAFLD in Canada

NAFLD and NASH in Australia

Australia's NAFLD Problem

A Snapshot of Obesity in Australia

Increasing Incidence of NASH as an Indication for LT

Natural History of NAFLD: A Multinational Cohort Study

Natural History of NAFLD: A Multinational Cohort Study Findings

Implications for Australia

NAFLD and NASH: The Global Epidemic

Obesity: At the Root of the Problem

NAFLD: A Spectrum of Disease

NAFLD and NASH: A Global Epidemic

Multiple Clinical Outcomes of NAFLD and NASH

Evidence for Progression of NASH

Forecast for Progression of NAFLD in 2015 to 2030

Forecast for Progression of NAFLD in 2015 to 2030 (cont)

NAFLD Is Associated With Multiple Conditions

Improvement in Fibrosis Improves Quality of Life

NASH Associated With High Lifetime Economic Burden

Strategies to Decrease NASH Prevalence It Begins With Identifying Patients at Risk

Off-Label Pharmacologic Treatments

Targets in the Treatment Pipeline

Drugs in Phase 2 and Phase 3 Trials for NASH

Drugs in Phase 3 Trials for NASH

REGENERATE: Positive Results of OCA Treatment for NASH

Summary: NASH

Abbreviations

Abbreviations (cont)