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More Than Meets the Eye: Identifying Who Is at Risk for NASH

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Presentation on theme: "More Than Meets the Eye: Identifying Who Is at Risk for NASH"— Presentation transcript:

1 More Than Meets the Eye: Identifying Who Is at Risk for NASH

2 NAFLD: Hepatic Manifestation of Metabolic Syndrome

3 NASH: From Steatosis to Cirrhosis

4 Prevalence of NAFLD Growing in Parallel With Obesity and Metabolic Syndrome

5 Patients at Risk for NASH How Do You Spot Them?

6 NASH in the Asia-Pacific Region

7 Case 1: 32-Year-Old Caucasian Man With Fatty Liver Seen In Ultrasound

8 Case 2: 60-Year-Old Hispanic Man With Well-Controlled Diabetes

9 Stratifying Risk for NASH It's Not All About Lab Values

10 The Genetic Component of NASH I148M PNPLA3 and Progressive Liver Disease

11 NASH Is a Phenotype Multi-Hit Pathogenesis

12 Ballooning: A Histologic Feature of NAFL

13 Natural History of NAFLD

14 HCC in NAFLD: Occurs In Patients With and Without Cirrhosis

15 NAFLD/NASH-Associated HCC Tumor Burden Is High

16 Ultrasound in NASH Not an Optimal Tool

17 NASH: Fast Becoming Leading Indication for Liver Transplantation in the United States

18 Progression of NAFLD Is Not Linear Fibrosis Is a Moving Target

19 NAFLD: Factors Related to Progression vs Regression

20 Using Clinical Parameters to Predict Outcomes

21 Biomarkers for NASH: What's In the Toolkit Now?

22 Why Is Assessment of Fibrosis vs NASH Important?

23 Patient- and Healthcare-Related Outcomes

24 Concluding Remarks

25 Abbreviations

26 Abbreviations (cont)


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