FAK overexpression in invasive human breast cancer and DCIS

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FAK overexpression in invasive human breast cancer and DCIS FAK overexpression in invasive human breast cancer and DCIS. A, paired samples of normal breast (NOR) and invasive breast cancer (INV) from the same patient demonstrate no detectable FAK expression in the normal tissue. FAK overexpression in invasive human breast cancer and DCIS. A, paired samples of normal breast (NOR) and invasive breast cancer (INV) from the same patient demonstrate no detectable FAK expression in the normal tissue. In contrast, the invasive breast cancer cells (INV) demonstrate intense membrane and cytoplasmic immunoreactivity for p125FAK. Note the absence of immunoreactivity in the surrounding tumor-infiltrating lymphocytes (immunohistochemistry, ×600). B, in this single FFPE tissue section, the focus of DCIS (DCIS) expresses p125FAK at a slightly lower level than the adjacent focus of infiltrating ductal carcinoma (INV; left; ×200). These two areas are shown at higher magnification (×600) to demonstrate this difference (DCIS, middle; INV, right). William G. Cance et al. Clin Cancer Res 2000;6:2417-2423 ©2000 by American Association for Cancer Research