PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC

Slides:

Advertisements

Similar presentations

Antitumor effect of the combination of IL-2 IC and anti–CTLA-4.

Advertisements

A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.

Andrea L Kasinski, Frank J Slack Molecular Therapy - Nucleic Acids

Effects of SC144 on in vivo ovarian tumor.

The STM1787 promoter in Salmonella is rapidly activated in vivo by the tumor microenvironment. The STM1787 promoter in Salmonella is rapidly activated.

H31m1-PDL1 cells form progressively growing tumors in WT mice.

Validation of St6GalNAc2 as a metastasis suppressor gene.

Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.

Volume 19, Issue 8, Pages (August 2011)

Activity of MAC-321 (i. v. and p. o

Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Highly related T9 and T3 sarcoma.

Mouse lymphoma model. Mouse lymphoma model. A, EL-Arf−/− cells (1 × 106) were tail-vein injected into C57BL/6 mice. LNIWC imaging was separated into 2.

Fig. 6 RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. RUNX/CBFB interaction inhibitor, Ro5-3335,

PTB-independent ShcA pools require Src to promote mammary tumorigenesis. PTB-independent ShcA pools require Src to promote mammary tumorigenesis. A, Src.

Antitumor immunity caused by DS-8201a.

Gramicidin A (GA) decreases HIF protein expression in RCC cells.

PTENP1 expression is downregulated in ccRCC.

In vivo assessment of synergistic activity of MV-CEA and RT in a U87 s

Effect of HA on hematopoietic recovery in tumor-bearing mice.

PTENP1 sensitizes renal cancer cells to chemotherapy.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

Subcutaneous tumor growth was significantly increased in Ogt-Tg/+ mice

Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model in vivo. Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model.

NSG mice transplanted with human primary ALK-positive ALCL tumor grafts were administered either doxorubicin, 10 mg/kg i.v. or CEP orally, 100 mg/kg,

coTCRcys-transduced T cells control tumor growth in vivo.

Effects of DPM treatment on tumor volume, tumor mass, and pulmonary metastasis at experimental end point. Effects of DPM treatment on tumor volume, tumor.

In vivo growth-inhibitory effect of perifosine on bevacizumab-resistant CCC. A, the effect of bevacizumab (BEV) on CCC growth in vivo. In vivo growth-inhibitory.

PRIMA-1Met inhibits the growth of multiple myeloma tumors with mutant p53 in vivo. PRIMA-1Met inhibits the growth of multiple myeloma tumors with mutant.

Matriptase-2 inhibited breast tumor development in vivo.

The effect of IAA on tumor growth in an SK-MEL-28 xenograft model.

MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.

PD-L1 expressed on edited T3 sarcoma cells prevents their immune elimination. PD-L1 expressed on edited T3 sarcoma cells prevents their immune elimination.

GA reduces the growth of Caki-1 tumor xenografts.

In vivo tumorigenicity of MKN-1 cells with sustained suppression of HDAC2. In vivo tumorigenicity of MKN-1 cells with sustained suppression of HDAC2. A,

PPP2R2A overexpression rescues the miR-21–induced biological effects in bladder cancer cells. PPP2R2A overexpression rescues the miR-21–induced biological.

In vivo efficacy of targeted EDVTM in an orthotopic neuroblastoma mouse model with high EGFR protein levels. In vivo efficacy of targeted EDVTM in an orthotopic.

Antitumor effects of celastrol in vitro and in vivo.

Xenograft regrowth studies.

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

The effect of different concentrations of WMC-79 and time of exposure on the growth of HCT-116 cells. The effect of different concentrations of WMC-79.

GM-CSF is required for CA-MSC–induced tumor metastasis.

Effect of the crystal form and solid dispersion preparations of KRN633 on the growth of human tumor xenografts in mice. Effect of the crystal form and.

A, tumor growth studies in H1975 tumor–bearing mice.

miR-100 suppresses bladder cancer cell growth in vitro and in vivo.

CRA inhibits the growth of human tumor xenografts in vivo.

NT157 treatment inhibits LNCaP xenograft growth and delays castration-resistant progression. NT157 treatment inhibits LNCaP xenograft growth and delays.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

HMQ1611 inhibited breast tumor growth in mice.

In vivo bioluminescence imaging of primary tumors and tumor metastasis

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

C7R enhances adoptive T-cell immunotherapy against metastatic and intracranial malignancies.A and B, 1 × 106 CHLA-255 FFluc cells were injected i.v. into.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Putative molecular pathways showing how GSK3β regulates the fate of tumor cells (survival, proliferation, or apoptosis) and influences their sensitivity.

A, VEGFR2 staining in the tumor rim and center.

BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. A, CWR22RV1.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Targeting GAPLINC decreased CD44 expression and tumor growth in vivo.

Proliferation of TA3-Ha and TA3-St cells in vitro and in vivo.

PDL192 and inhibit the growth of xenograft tumors.

MYC expression is correlated with dasatinib sensitivity in cancer cell lines and in vivo. MYC expression is correlated with dasatinib sensitivity in cancer.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination.

Increased tumorigenic activities of TIM-3–expressing RCC cells.

Effect of HDC on the ROS production in mouse lungs after melanoma cell inoculation. Effect of HDC on the ROS production in mouse lungs after melanoma cell.

Validation of KMT2D function in MM23, MM2, and MM25 PDXs

In vivo effect of KIN-193 on PTEN-deficient tumors.

PD-L1 expression is not associated with PTEN expression status in melanomas. PD-L1 expression is not associated with PTEN expression status in melanomas.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

Presentation transcript:

PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. A, cell proliferation in ACHN and SN12PM6 cells expressing miR21 or control. PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. A, cell proliferation in ACHN and SN12PM6 cells expressing miR21 or control. Cell viability was quantified at each time point. miR21 promoted cell growth. Data are plotted as the mean ± SEM of three independent experiments. B, cell proliferation in ACHN and SN12PM6 cells expressing PTEN or control. Cell viability was quantified at each time point. PTEN suppressed cell growth. C, cell proliferation in ACHN and SN12PM6 cells expressing vector control or PTENP1 or miR21 or miR21 and PTENP1. Cell viability was quantified at each time point. PTENP1 reversed the promotion of cell growth by miR21. D, we designed five groups in the animal models, and then ACHN cells expressing vector control or miR21 or PTEN, or PTENP1 or coexpressing miR21 and PTENP1 were transplanted into mice. D, the size of transplanted tumors in different groups (a). Tumor weight of each mouse at the end of 41 days is indicated (b). Tumor volumes were determined at each time point (c). PTEN and PTENP1 suppressed tumor growth in vivo. miR21 promoted tumor growth in vivo. PTENP1 rescued the promotion of tumor growth by miR21. These data mean PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. **, P < 0.01. Gan Yu et al. Mol Cancer Ther 2014;13:3086-3097 ©2014 by American Association for Cancer Research