Regulation of Tubular Reabsorption

Slides:

Advertisements

Similar presentations

The Urinary System: Fluid and Electrolyte Balance

Advertisements

David Sadava H. Craig Heller Gordon H. Orians William K. Purves David M. Hillis Biologia.blu C – Il corpo umano Excretory System and Salt and Water Balance.

Bio& 242: Unit 2 / Lecture 1.

Glomerulotubular Balance-The Ability of the Tubules to Increase Reabsorption Rate in Response to Increased Tubular Load.

The Urinary System $100 $100 $100 $100 $100 $200 $200 $200 $200 $200

Tubular Reabsorption Figure 27-1; Guyton and Hall.

Lecture 5 Regulation of Sodium and Water Excretion ….. essentially same as….. Regulating Plasma Volume and Osmolarity.

Functions of the kidney

Hormone Regulation of Urine Formation

Renal Structure and Function. Introduction Main function of kidney is excretion of waste products (urea, uric acid, creatinine, etc). Other excretory.

Chapter 26 Urinary System.

Human Urogenital System

Renal (Urinary) System

Control of Renal Function. Learning Objectives Know the effects of aldosterone, angiotensin II and antidiuretic hormone on kidney function. Understand.

Major Functions of the Kidneys and the Urinary System

Reabsorption and Secretion. Learning Objectives Understand how fluid flow from the tubular lumen to the peritubular capillaries. Know how the reabsorption.

Role of Kidneys In Regulation Of Potassium Levels In ECF

Urinary System and the Excretion System

Renal Jeopardy J. Ellen Lathrop-Davis Community College of Baltimore County 800 South Rolling Road, Baltimore, MD 21228

Urinary System. A. Functions - regulates volume, composition, and pH of body fluids; excretes N and S wastes; controls red blood cell production; regulates.

Unit Five: The Body Fluids and Kidneys

Lecture – 3 Dr. Zahoor 1. TUBULAR REABSORPTION  All plasma constituents are filtered in the glomeruli except plasma protein.  After filtration, essential.

Cells Respond to Their External Environments Chapter 8.

D. C. Mikulecky Faculty Mentoring Program Virginia Commonwealth Univ. 10/6/2015.

Regulation of Body Fluid Balance. Osmotic Relations Between Intracellular Fluid, Interstitial Fluid and Plasma protein Na + protein Na + H2OH2O K+K+ H2OH2O.

NEPHROLOGY: THE MAKING OF URINE

BLOCK: URIN 313 PHYSIOLOGY OF THE URINARY SYSTEM LECTURE 3 1 Dr. Amel Eassawi.

The Urinary System.

BIO – 255 Anatomy & Physiology Chapter 25 – Urinary System.

IPHY /27/11. Materials filtered into Bowman ’ s capsule Water Ions glucose, amino acids wastes (NH3, urea, etc) a few plasma proteins everything.

Driving Force of Filtration n The filtration across membranes is driven by the net filtration pressure n The net filtration pressure = net hydrostatic.

P. 954 Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings © 2012 Pearson Education, Inc.

Tubular reabsorption and tubular secretion

RENAL FUNCTIONS & GFR Dr. Eman El Eter. What are the functions of the kidney?  Regulation of water and electrolyte balance.  Regulation of body fluid.

CHAPTER 15 Urinary System. Kidney Functional Units No direct exchange – substances diffuse through interstitial fluid Renal artery/vein: kidney blood.

Physiology of the Urinary System

Human Physiology Physiology of the Kidneys Chapter 13.

Human Anatomy and Physiology Renal function. Functions Regulation of water and electrolytes Maintain plasma volume Acid-base balance Eliminate metabolic.

Blood Pressure Regulation- Background info ► Water will go where there are high concentrations of Salt ► Increase in water = increase in volume ► Increase.

RENAL PHYSIOLOGY Origin of the Hyperosmotic Renal Medulla

Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Reabsorption and Secretion  ADH  Hormone that causes special water.

Regulation of Na +, K + and water Chapter 14 pages

1 Table Filtration, Reabsorption, and Excretion Rates of Different Substances by the Kidneys GlucoseUrea Amount FilteredAmount ReabsorbedAmount Excreted%

Answers to renal physiology problems worked in class Robert G. Carroll, Ph.D. Brody School of Medicine East Carolina University View presentation using.

Tubular Reabsorption and regulation of tubular reabsorption Tortora Ebaa M Alzayadneh, PhD.

Tubular reabsorption.

Chapter 18 Lecture Slides

Tubular reabsorption.

Exam Four material Assignment due: Exam Four: Chapter 20 Urinary

Chapter 21 The Urinary System

Kidney Functions and regulation

Chapter 21 The Urinary System

Lecture-5 Regulation of Tubular Reabsorption

RENAL SYSTEM PHYSIOLOGY

Renal Physiology Functions of the kidneys Structures of the kidney

D. C. Mikulecky Faculty Mentoring Program Virginia Commonwealth Univ.

Urine Formation Is a result of three processes which help to regulate the blood composition and volume Filtration Reabsorption Secretion Function of Nephron.

TUBULAR REABSORPTION Part II

Kidney Functions and regulation

ANATOMY AND PHYSIOLOGY

% of Filtered Load Reabsorbed

Tubular processing of the glomerular filtrate. The renal tubules process the glomerular filtrate by: Reabsorption: Transport of a substance from the tubular.

Kidneys and Homeostasis

  The Body Fluids and Kidneys Lecture 16 KEEP OFF YOUR MOBILE PHONES

Excretory System Blood Pressure Hormones.

Kidney Functions and regulation

REGULATION OF K,Ca, PHOSPHATE & MAGNISIUM

Regulation of tubular reabsorption

Hormonal Control of Tubular Reabsorption HORMONES THAT REGULATE ABSORPTION EFFECTS Aldosterone ↑ NaCl,H2 O reabsorption, ↑ K+ secretion Angiotensin.

Presentation transcript:

Regulation of Tubular Reabsorption Kidney lecture 14 The Body Fluids and Kidneys Lecture 14 Urine Formation II Regulation of Tubular Reabsorption Dr. Rashid Mahmood

Regulation of Tubular Reabsorption Kidney lecture 14 Regulation of Tubular Reabsorption Dr. Rashid Mahmood

Reabsorption=124 ml/min Reabsorption= Kf × Net Reabsorptive Force Kf = Capillary Co-Efficient = Permeability × Surface Area

Reabsorptive Force

Regulation of Peritubular Capillary Physical Forces Arterial Pressure: ↑ BP : ↓ Reabsorption ( ↑ Pc ) 2. Resistance of Afferent & Efferent Arterioles: ↑ Resistance: ↓ Pc : ↑ Reabsorption 3. Systemic Colloid Osmotic Pressure: ↑ π c: ↑ Reabsorption 4. Filtration Fraction: ↑ π c: Reabsorption

Forces that increase/decrease peritubular capillary reabsorption also increases/decreases reabsorption from renal tubules

Pressure Diuresis Pressure Natriuresis ↑ BP → ↑ GFR ↑ BP → ↑ Pc →↓ Reabsorption ↓ Angiotensin-II

Hormonal Control of Tubular Reabsorption

HORMONES THAT REGULATE ABSORPTION EFFECTS Aldosterone ↑ NaCl,H2 O reabsorption, ↑ K+ secretion Angiotensin -II ↑ NaCl,H2 O reabsorption, ↑H+ secretion Antidiuretic Hormone ↑H2 O reabsorption Atrial Natriuretic Peptide ↓ NaCl reabsorption Parathyroid Hormone ↓ Phosphate Reabsorption , ↑ Ca++ Reabsorption

Angiotensin-II ↑ Aldosterone Constriction of Efferent Arterioles i. ↓Pc → ↑ Reabsorption ii. ↓ Renal Blood Flow → ↑ Filtration Fraction → ↑ πc → ↑ Reabsorption Direct stimulation of Sodium Reabsorption Stimulation of Na+,K+ ATPase Stimulation of Na+,H+ Counter-transport Sodium bicarbonate co transport

Effect of Angiotensin-II on Na+ and Water Reabsorption ↑ADH OVLT→Hypothalamus Angiotensin-II ↑ thirst ↑ Aldosterone Constriction of efferent arterioles Direct stimulation of Sodium Reabsorption ↓ Renal Blood Flow ↓Pc Stimulation of Na+,K+ ATPase ↑ Filtration Fraction Stimulation of Na+,H+ Counter-transport ↑ πc ↑ Reabsorption ↑ Na+ Reabsorption

Effect of Angiotensin-II on Na+ and Water Reabsorption ↑ADH OVLT→Hypothalamus Angiotensin-II ↑ thirst ↑ Aldosterone Constriction of efferent arterioles Direct stimulation of Sodium Reabsorption ↓ Renal Blood Flow ↓Pc Stimulation of Na+,K+ ATPase ↑ Filtration Fraction Stimulation of Na+,H+ Cotransport ↑ πc ↑ Reabsorption ↑ Na+ Reabsorption

HORMONES THAT REGULATE ABSORPTION EFFECTS Aldosterone ↑ NaCl,H2 O reabsorption, ↑ K+ secretion Angiotensin -II ↑ NaCl,H2 O reabsorption, ↑H+ secretion Antidiuretic Hormone ↑H2 O reabsorption Atrial Natriuretic Peptide ↓ NaCl reabsorption Parathyroid Hormone ↓ Phosphate Reabsorption , ↑ Ca++ Reabsorption

Anti-diuretic hormone Site of action Late distal tubules, collecting tubules, collecting ducts Binds to specific V2 receptors → movement of an intracellular protein, AQP-2 (Aquaporin-2) to luminal side of cell → molecules of AQP-2 fuse with cell membrane by exocytosis → water channels →↑ water permeability