Upper Zone Threshold (bpm) Lower Zone Threshold (bpm)

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Upper Zone Threshold (bpm) Lower Zone Threshold (bpm) Supplement 2 Subjects (%) Upper Zone Threshold (bpm) 170 180 190 200 210 220 230 240 250 Single Zone 48.9% (22/45) 4.4% (2/45) 17.8% (8/45) 11.1% (5/45) 6.7% (3/45) 0% (0/45) 2.2% (1/45) Lower Zone Threshold (bpm) Dual Zone 0% (0/1579) 0.1% (1/1579) 0.4% (7/1579) 0.3% (4/1579) 1.1% (17/157 9) 0.9% (14/157 9) 0.6% (9/1579) 5.6% (88/157 9) 1.9% (30/157 9) 1.5% (23/157 9) 0.4% (6/1579) 27.9% (441/15 79) 8.1% (128/15 79) 14.4% (228/15 79) 12.8% (202/15 79) 1.8% (28/157 9) 2.3% (36/157 9) 3.1% (49/157 9) 2.3% (37/157 9) 3.7% (58/157 9) Figure 3. 30 Day Complication Rate Zone Threshold Programming: Frequency of available rate cut-offs programmed at implant for patients programmed with single zone and dual zone discrimination algorithms, in beats per minute (bpm). Rates detected above the upper zone threshold are in the “shock zone” and rates detected between the lower zone threshold and upper zone threshold are in the “conditional zone”.