Julie Negri, BA, S. Brandon Early, BA, John W

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Presentation transcript:

Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways Julie Negri, BA, S. Brandon Early, BA, John W. Steinke, PhD, Larry Borish, MD Journal of Allergy and Clinical Immunology Volume 121, Issue 5, Pages 1232-1237 (May 2008) DOI: 10.1016/j.jaci.2008.02.007 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Modulation of monocyte CysLT secretion by IL-4 and fluticasone. Enriched monocytes were cultured with or without IL-4 (10 ng/mL) and with or without fluticasone (10−7 mol/L) for 48 hours and stimulated with LPS for 1 hour. Supernatants were collected and assayed for CysLT secretion by means of ELISA. Journal of Allergy and Clinical Immunology 2008 121, 1232-1237DOI: (10.1016/j.jaci.2008.02.007) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Modulation of CysLT receptor mRNA expression in monocytes by IL-4 and fluticasone. Monocytes were cultured with or without IL-4 (10 ng/mL) and with or without the additional presence of fluticasone (10−9 and 10−7 mol/L). CysLT1R (A) and CysLT2R (B) mRNA expression was determined by means of quantitative PCR (qPCR), and data are expressed in comparison with that for monocytes not exposed to IL-4 or fluticasone. Data represent means ± SEMs of 10 replicate experiments. Journal of Allergy and Clinical Immunology 2008 121, 1232-1237DOI: (10.1016/j.jaci.2008.02.007) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Modulation of CysLT1R (A) and CysLT2R (B) expression on T lymphocytes by IL-4 and fluticasone. TH lymphocytes were cultured with IL-4 (10 ng/mL) with or without fluticasone (10−7 mol/L). Cells were labeled with rabbit polyclonal anti-CysLT receptor antibodies followed by phycoerythrin-conjugated goat anti-rabbit IgG and evaluated by means of flow cytometry. No inhibition of IL-4–induced CysLT1R expression was observed. Fluticasone decreased mean fluorescence of CysLT2R from 40.5 to 30.7. Ab, Antibody. Journal of Allergy and Clinical Immunology 2008 121, 1232-1237DOI: (10.1016/j.jaci.2008.02.007) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions