Cell Migration: Recoiling from an Embrace Miriam A. Genuth, Orion D. Weiner  Current Biology  Volume 25, Issue 13, Pages R566-R568 (June 2015) DOI: 10.1016/j.cub.2015.05.015 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Different modes of CIL. (A) In Xenopus neural crest, N-cadherin engagement activates planar cell polarity (PCP) signalling, leading to focal activation of RhoA and myosin II at the site of cell–cell contact and local retraction [2]. This mode of CIL can occur with any orientation of collision. (B) Drosophila hemocytes utilize the contractile forces that generate retrograde flow for retraction in CIL [7]. When cells collide, adhesions couple the cytoskeleton to the plasma membrane, leading to an increase in lamellar tension that causes the cells to recoil when the adhesions are released. This mode of CIL only occurs for lamellar-to-lamellar (i.e. front-to-front) collisions. Current Biology 2015 25, R566-R568DOI: (10.1016/j.cub.2015.05.015) Copyright © 2015 Elsevier Ltd Terms and Conditions