Update on risk factors for food allergy

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Presentation transcript:

Update on risk factors for food allergy Gideon Lack, MD Journal of Allergy and Clinical Immunology Volume 129, Issue 5, Pages 1187-1197 (May 2012) DOI: 10.1016/j.jaci.2012.02.036 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Dual-allergen exposure hypothesis for the pathogenesis of FA. Allergic sensitization results from cutaneous exposure, and tolerance occurs as a result of oral exposure to food. GI, Gastrointestinal. Reprinted with permission from Lack.1 Journal of Allergy and Clinical Immunology 2012 129, 1187-1197DOI: (10.1016/j.jaci.2012.02.036) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 PA among children with FA (n = 293) as a function of environmental exposure depending on whether child first ate peanuts by 12 months of age. Reprinted with permission from Fox et al.67 Journal of Allergy and Clinical Immunology 2012 129, 1187-1197DOI: (10.1016/j.jaci.2012.02.036) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Early consumption of peanuts in infancy is associated with a low prevalence of PA. Adapted from Du Toit et al.13 Journal of Allergy and Clinical Immunology 2012 129, 1187-1197DOI: (10.1016/j.jaci.2012.02.036) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Ratio of stimulation index (SI) in the cutaneous lymphocyte antigen (CLA) subset relative to the SI in the α4β7 subset for patients with PA (n = 10) and nonallergic patients (NA; n = 10) with 400 μg/mL peanut antigen and OVA. Median values are represented by bars. Journal of Allergy and Clinical Immunology 2012 129, 1187-1197DOI: (10.1016/j.jaci.2012.02.036) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions