Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic steatosis. Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic.

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Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic steatosis. Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic steatosis. Eight-week-old male L-KO PPARγ mice were fed an HFD supplemented with acetate, propionate, or butyrate (5% w/w). A: Body weight was measured for 10 weeks. *P < 0.05 acetate vs. control; #P < 0.05 propionate vs. control; $P < 0.05 butyrate vs. control. B: Insulin tolerance tests were performed on mice after 9 weeks on the indicated diets and after a 4-h fast. C: Liver triglycerides in mice after 10 weeks on the indicated diets. D: Fatty acid β-oxidation in liver and WAT was measured in mice after 10 weeks on the indicated diets. E: PPARγ, UCP2, pAMPK, and pACC protein levels were assessed by Western blot in liver and WAT lysates. Values are means ± SEM for n = 6–8. *P < 0.05 vs. control. Gijs den Besten et al. Diabetes 2015;64:2398-2408 ©2015 by American Diabetes Association