Fig. 2 LYM attractor metagene.

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Fig. 2 LYM attractor metagene. LYM attractor metagene.(A and B) Kaplan-Meier cumulative survival curves of ER-negative breast cancer patients over a 15-year period on the basis of LYM attractor metagene expression—represented by the LYM feature—in the (A) METABRIC and (B) OsloVal data sets. The ER-negative breast cancer patients were divided into equal-sized high and low LYM-expressing subgroups according to their ranking with respect to expression values of the LYM feature. High expression of the LYM attractor metagene was associated with improved survival in both data sets. P values derived using the log-rank test in the two data sets were 0.0024 and 0.0223, respectively. (C) Kaplan-Meier cumulative survival curves of ER-positive breast cancer patients with more than four positive lymph nodes over a 15-year period on the basis of LYM attractor metagene expression—represented by the LYM feature—in the METABRIC data set. ER-positive breast cancer patients with more than four positive lymph nodes were divided into equal-sized high and low LYM-expressing subgroups according to their ranking with respect to expression values of the LYM feature. In contrast to (A), high expression of the LYM attractor metagene was associated with poorer survival in this patient subset. The P value derived using the log-rank test was 0.0278. There were only 19 corresponding samples in the OsloVal data set, insufficient for validation of this reversal relative to (B). Wei-Yi Cheng et al., Sci Transl Med 2013;5:181ra50 Copyright © 2013, American Association for the Advancement of Science