DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.

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DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with various clinical and biochemical parameters (clinical study 2). DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with various clinical and biochemical parameters (clinical study 2). A and B: Samples of adipose tissue were obtained from lean controls (n = 10) and obese patients before (n = 19) and after (n = 16) bariatric surgery, and used to generate explants as described in research design and methods. The size of adipocytes for each subject was measured (A). DPP4 release was analyzed by ELISA and related to the quantity of adipocytes (B). C: DPP4 serum concentration was measured in lean and obese patients before and after bariatric surgery. D–K: Linear regression analysis of DPP4 release per 107 cells and patient characteristics such as BMI (D), waist circumference (E), percent of body fat (F), HDL-cholesterol concentration (G), triglycerides concentration (H), HOMA (I), adipocyte volume (J), and leptin (K). A–C: Data are mean values ± SEM. *P < 0.05 between respective groups. Daniela Lamers et al. Diabetes 2011;60:1917-1925 ©2011 by American Diabetes Association