Gene set enrichment analysis reveals MafA regulation of many key β-cell activities. Gene set enrichment analysis reveals MafA regulation of many key β-cell.

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Gene set enrichment analysis reveals MafA regulation of many key β-cell activities. Gene set enrichment analysis reveals MafA regulation of many key β-cell activities. (A) The mRNA expression levels of 13 MafA microarray identified candidate genes in 3-week-old Mafa∆panc and control islets (n ≥ 3). *P < 0.05; **P < 0.01; ***P < 0.001. Gene ontology analysis showing the (B) cellular component and (C) molecular function enrichment obtained from the microarray mRNA studies performed on 3-month-old wild-type and Mafa∆panc islets. Each pie chart section is proportional to the number of genes in the category. The acinar cell signals in the Mafa∆panc microarray data are contamination, since these were not detected in the independently isolated Mafa∆panc islet preparations used for Figs. 4 and 6. (D) Signaling pathway impact analysis illustrates those significantly altered in Mafa∆panc islets. Each dot represents a unique signaling pathway, with those labeled with an identification number most significantly perturbed. A red dot denotes a significance of P < 0.05 after Bonferroni correction and blue P < 0.05 after false discovery rate correction. ECM, extracellular matrix; GO, gene ontology; MAPK, mitogen-activated protein kinase; P NDE, probability of number of differentially expressed genes; P PERT, probability of perturbation; SPIA, signaling pathway impact analysis; TGF, transforming growth factor. Yan Hang et al. Diabetes 2014;63:1994-2005 ©2014 by American Diabetes Association