AZD2563, a novel oxazolidinone: definition of antibacterial spectrum, assessment of bactericidal potential and the impact of miscellaneous factors on.

Slides:



Advertisements
Similar presentations
Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages
Advertisements

Clinical impact of a real-time PCR assay for rapid identification of Staphylococcus aureus and determination of methicillin resistance from positive blood.
Gut bacterial microbiota and obesity
Molecular characterization of methicillin-resistant Staphylococcus aureus isolated over a 2-year period in a Qatari hospital from multinational patients 
D. Khalil, M. Hultin, M.U. Rashid, B. Lund 
Antimicrobial resistance in viridans group streptococci among patients with and without the diagnosis of cancer in the USA, Canada and Latin America 
P. Clarke, S. Murchan, E.G. Smyth, H. Humphreys 
European perspective and update on the management of nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus after more than 10 years.
The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram- positive bacteria  M.J. Rybak  Clinical Microbiology and Infection 
In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin- resistant Acinetobacter baumannii  X. Vila-Farres, C. Garcia.
Antimicrobial Activity of SCH 27899, Oligosaccharide Member of the Everninomycin Class with a Wide Gram-Positive Spectrum  Ronald N. Jones, M.D., Mary.
European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after.
A.K. Reddy, P. Garg, I. Kaur  Clinical Microbiology and Infection 
In-vitro susceptibility and molecular characterisation of macrolide resistance mechanisms among Streptococcus pneumonia isolates in The Netherlands: the.
J.-P. Van geertruyden  Clinical Microbiology and Infection 
In vitro activity of cefpirome and vancomycin in combination against gentamicin- susceptible and gentamicin-resistant Staphylococcus aureus  A. Carricajo,
Clinical impact of antibiotic-resistant Gram-positive pathogens
Quinolone resistance among Shigella spp
European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after.
Louis Pasteur, from crystals of life to vaccination
How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development  R. Bax  Clinical Microbiology.
Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?  T. Coenye, D. Goeres, F. Van Bambeke, T. Bjarnsholt 
Use of surveillance cultures and enteral vancomycin to control methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit  K. Thorburn,
AZD2563, a novel oxazolidinone: definition of antibacterial spectrum, assessment of bactericidal potential and the impact of miscellaneous factors on.
Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan  P.R. Hsueh, S.P. Tseng, L.J. Teng, S.W. Ho 
W. Witte, B. Pasemann, C. Cuny  Clinical Microbiology and Infection 
H. Adibhesami, M. Douraghi, M. Rahbar, A. Abdollahi 
Tracking changes in the vraSR and graSR two component regulatory systems during the development and loss of vancomycin non-susceptibility in a clinical.
Vector control: a cornerstone in the malaria elimination campaign
Sofie Arens, Jan Verhaegen, Ludo Verbist 
Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci.
E.C. Böttger  Clinical Microbiology and Infection 
Low prevalence of methicillin-resistant Staphylococcus aureus with reduced susceptibility to glycopeptides in Belgian hospitals  C. Nonhoff, O. Denis,
Bacterial resistance—the clinical challenge
Comparative in vitro activity of ertapenem against bacterial pathogens isolated from patients with lower respiratory tract infections  P.S. Hicks, B.
Evaluation of vancomycin MIC creep in methicillin-resistant Staphylococcus aureus infections—a systematic review and meta-analysis  R. Diaz, V. Afreixo,
Elements of design: the knowledge on which we build
Metagenomics and probiotics
M. Aires-de-Sousa  Clinical Microbiology and Infection 
Clinical profile of ceftobiprole, a novel β-lactam antibiotic
Laboratory diagnosis of Clostridium difficile disease
Recent developments in staphylococcal scalded skin syndrome
A. Bryskier  Clinical Microbiology and Infection 
The practice of travel medicine in Europe
T.M. File  Clinical Microbiology and Infection 
Single- and multistep selection study of the antipneumococcal activity of BMS compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin 
Update on antifungal resistance in Aspergillus and Candida
Harmonised monitoring of antimicrobial resistance in Salmonella and Campylobacter isolates from food animals in the European Union  S. Bronzwaer  Clinical.
Antibacterial drug discovery in the 21st century
P.M. Hawkey  Clinical Microbiology and Infection 
Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan 
Circulation of international clones of levofloxacin non-susceptible Streptococcus pneumoniae in Taiwan  Y.-C. Hsieh, L.-Y. Chang, Y.-C. Huang, H.-C. Lin,
Definition of the Clinical Antibacterial Spectrum of Activity
G.M. Rossolini, E. Mantengoli  Clinical Microbiology and Infection 
Clinical Microbiology and Infection
Facilitating learning and change in physicians: Implications for a system of continuing medical education in Europe  Robert D. Fox  Clinical Microbiology.
Modelling during an emergency: the 2009 H1N1 influenza pandemic
J. Wilson, S. Elgohari, D. M. Livermore, B. Cookson, A. Johnson, T
In vitro activity of evernimicin and selected antibiotics against methicillin-resistant staphylococci: a 24-country study  R. Goering, C.-E. Nord, R.
A. Manzur, F. Gudiol  Clinical Microbiology and Infection 
B.A. Cunha  Clinical Microbiology and Infection 
Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group†   H. Goossens  Clinical.
J.L. Balcázar  Clinical Microbiology and Infection 
Test results: characterising the antimicrobial activity of daptomycin
G.C. Schito  Clinical Microbiology and Infection 
The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands  J.W. Mouton, A.R. Jansz  Clinical.
Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3- ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant.
Impact of antibiotic restrictions: the patient's perspective
Activity of linezolid against Gram-positive cocci isolated in French hospitals as determined by three in-vitro susceptibility testing methods  C. Muller-Serieys,
The future of diagnostic bacteriology
Presentation transcript:

AZD2563, a novel oxazolidinone: definition of antibacterial spectrum, assessment of bactericidal potential and the impact of miscellaneous factors on activity in vitro  A. Wookey, P.J. Turner, J.M. Greenhalgh, M. Eastwood, J. Clarke, C. Sefton  Clinical Microbiology and Infection  Volume 10, Issue 3, Pages 247-254 (March 2004) DOI: 10.1111/j.1198-743X.2004.00770.x Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Structure of AZD2563. Clinical Microbiology and Infection 2004 10, 247-254DOI: (10.1111/j.1198-743X.2004.00770.x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Cumulative percentage susceptibilities for AZD2563 and linezolid against recent clinical isolates (MR, Methicillin-resistant; MS, Methicillin-susceptible). Clinical Microbiology and Infection 2004 10, 247-254DOI: (10.1111/j.1198-743X.2004.00770.x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Time-kill assay for recent clinical isolates tested with AZD2563, linezolid and vancomycin at four times their respective MICs (MR, Methicillin-resistant). Clinical Microbiology and Infection 2004 10, 247-254DOI: (10.1111/j.1198-743X.2004.00770.x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions