Higher risk of opioid-induced respiratory depression in children with neurodevelopmental disability: a retrospective cohort study of 12 904 patients

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Presentation transcript:

Higher risk of opioid-induced respiratory depression in children with neurodevelopmental disability: a retrospective cohort study of 12 904 patients M.A. Jay, B.M. Thomas, R Nandi, R.F. Howard British Journal of Anaesthesia Volume 118, Issue 2, Pages 239-246 (February 2017) DOI: 10.1093/bja/aew403 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Posterior distributions of the effect of having neurodevelopmental disability on the risk of respiratory depression (a) and serious adverse events (b). AUC>1, area under the curve with an odds ratio >1; CrI, credibility interval. British Journal of Anaesthesia 2017 118, 239-246DOI: (10.1093/bja/aew403) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Plots showing the effect of morphine on the predicted probability of RD events (a) and SAE (b) in the NDG and CG. Dashed lines are 95% credibility intervals (credibility intervals represent the range of plausible predicted probabilities of events across the stated range of morphine doses that are predicted by the final model). CG, control group; NDG, neurodevelopmental disability group; RD, respiratory depression; SAE, serious adverse events. British Journal of Anaesthesia 2017 118, 239-246DOI: (10.1093/bja/aew403) Copyright © 2017 The Author(s) Terms and Conditions