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Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational.

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Presentation on theme: "Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational."— Presentation transcript:

1 Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational study  C.J. Malm, E.C. Hansson, J. Åkesson, M. Andersson, C. Hesse, C. Shams Hakimi, A. Jeppsson  British Journal of Anaesthesia  Volume 117, Issue 3, Pages (September 2016) DOI: /bja/aew189 Copyright © 2016 The Author(s) Terms and Conditions

2 Fig 1 Scatter plot of preoperative adenosine diphosphate (ADP)-induced aggregation and time since last dose of ticagrelor in ticagrelor-treated subjects. There was a linear correlation between the tested variables (R2=0.30, P<0.001). British Journal of Anaesthesia  , DOI: ( /bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

3 Fig 2 Receiver operating characteristic curve for the precision of adenosine diphosphate (ADP)-induced aggregation to predict severe bleeding. The cut-off value (22 U) had a sensitivity of 76% and a specificity of 75%. British Journal of Anaesthesia  , DOI: ( /bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

4 Fig 3 The distribution of the preoperative adenosine diphosphate (ADP)-induced aggregation values. The upper portion of the figure shows a scatter plot of the ADP-induced aggregation of the subjects with severe bleeding. The normal range of ADP-induced aggregation (43–100 U) is marked by a green background. British Journal of Anaesthesia  , DOI: ( /bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

5 Fig 4 Probability of severe bleeding in relation to the preoperative adenosine diphosphate (ADP)-induced aggregation. The grey area represents the 95% confidence interval. British Journal of Anaesthesia  , DOI: ( /bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions


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