Conserved patterns of Shh expression from mammals to teleosts.

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Conserved patterns of Shh expression from mammals to teleosts. Conserved patterns ofShh expression from mammals to teleosts. (A-C) At early somitogenesis (∼8-10 somites) stages, Shh transcript accumulates throughout the axial mesoderm (presumptive notochord) in mouse, chicken and zebrafish embryos and is already detectable in the forming floorplate of the zebrafish embryo. (D-F) By later somitogenesis stages, transcript is detectable throughout the ventral floor of the brain and neural tube but is beginning to dissipate from the notochord. Images reproduced from figure 3 of Fietz et al. (1994). Philip W. Ingham Development 2018;145:dev168898 © 2018. Published by The Company of Biologists Ltd