Schematic illustration of the concepts in the pathogenesis of rheumatoid arthritis associated-interstitial lung disease (RA-ILD). Schematic illustration.

Slides:

Advertisements

Similar presentations

Microbial Challenge Host Immuno- inflammatory response Connective tissue and bone metabolism Clinical signs of disease initiation and progression Environmental.

Advertisements

Tissue Repair Dr. Raid Jastania. What is Repair? When does regeneration occur? When does fibrosis occur? What are the consequences of fibrosis?

Vascular Endothelial Injury by Chlorpyrifos: Relationship to Brain Metastasis A. Hirani, S. Kang, M. Ehrich, Y.W. Lee Virginia Polytechnic Institute and.

Wound Healing Dr. Raid Jastania.

ARTHRITIS Rheumatoid Arthritis Presented By: Ali Raza Ansar Qudsia Sehar Hafsa Kabir Rheumatoid Arthritis Presented By: Ali Raza Ansar Qudsia Sehar Hafsa.

Lecture # 31 TISSUE REPAIR: REGNERATION, HEALING & FIBROSIS - 3 Dr. Iram Sohail Assistant Professor Pathology College Of Medicine Majmaah University.

Update on Advances in the Pathophysiology and Pathogenesis of IPF.

Wound repair in healthy lungs and IPF

Current concepts of celiac disease pathogenesis

Cardiovascular Disease Risk in Patients with Rheumatic Diseases

From: Pulmonary Atelectasis:A Pathogenic Perioperative Entity

Immune mediators of tissue remodelling and lung function impairment in tuberculosis. Immune mediators of tissue remodelling and lung function impairment.

Wound repair in healthy lungs and IPF

Figure 3 Proposed mechanisms underlying the links

Chlamydophila pneumoniae

Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients Stephany P. Monsanto, M.Sc.,

S. S. Pullamsetti, R. Savai, W. Janssen, B. K. Dahal, W. Seeger, F

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.

Figure 1 Location of HLA variants known to be associated

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Currently recognized factors that influence the development of scleroderma renal crisis Figure 1 | Currently recognized factors that influence.

(A) EULAR response based on DAS28 (ESR, otherwise CRP) and (B) Boolean remission, at 6 months in patients treated with abatacept as a first-line biologic.

Figure 3 Hypothetical mechanisms of smoking-associated

Figure 2 Interaction effects between heterozygous HLA‑DRB1

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Rheumatol. doi: /nrrheum

Inflammatory and immune cells involved in chronic obstructive pulmonary disease (COPD). Inflammatory and immune cells involved in chronic obstructive pulmonary.

Volume 146, Issue 5, Pages (May 2014)

Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions Batya B. Davidovici, Naveed Sattar,

Figure 1 Cytokine titers determined by the multiplex bead assay Plotted are cytokine titers (pg/mL) in CSF of patients with other noninflammatory neurologic.

Inflammation: The classic double-edged sword

High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.

Figure 2 GM-CSF — a key player in inflammation and autoimmunity

The key pathological mechanisms underlying vascular changes in pulmonary hypertension (PH). The key pathological mechanisms underlying vascular changes.

Mean change from baseline CDAI in abatacept and TNFi initiators with a typical patient profile. Mean change from baseline CDAI in abatacept and TNFi initiators.

High Invasive Melanoma Cells Induce Matrix Metalloproteinase-1 Synthesis in Fibroblasts by Interleukin-1α and Basic Fibroblast Growth Factor-Mediated.

Volume 144, Issue 3, Pages (March 2013)

Reciprocal functions of hepatocyte growth factor and transforming growth factor-β1 in the progression of renal diseases: A role for CD44? Sandrine Florquin,

Extent of interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD. A simple stratification that utilises pulmonary function.

Mean change from baseline in disease and disability outcomes at 6 months for TNFi initiators by anti-CCP status. Mean change from baseline in disease and.

The gastrointestinal mucosa in health, CDI, and UC

Inflammatory responses elicited by e-liquid vaping.

Romain Gallet et al. BTS 2016;1:14-28

Pathogenesis of idiopathic pulmonary fibrosis (IPF).

Schematic overview of different immune processes in blood during the development of RA. Upper left: CD56dim NK cells are capable of killing autoimmune.

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

A summary of the pathogenesis, pathophysiology and clinical implications of the pulmonary vascular and cardiac abnormalities in interstitial lung disease.

Figure 4 Role of chemokines in dendritic cell migration

Transfusion-Related Acute Lung Injury

Proposed mechanisms for fibrointimal proliferation in pulmonary tumour thrombotic microangiopathy (PTTM). Proposed mechanisms for fibrointimal proliferation.

Clinical Gastroenterology and Hepatology

Figure 1 The role of macrophages in RA

Mechanisms of virus-induced airway inflammation in chronic obstructive pulmonary disease (COPD). Mechanisms of virus-induced airway inflammation in chronic.

Established and putative mediators and pathways involved in the pathogenesis of pulmonary arterial hypertension. Established and putative mediators and.

Molecular pathways underlying angiogenesis.

This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis.

Involvement of matrix metalloproteinases (MMPs) and interleukin (IL)-8 during human airway epithelial regeneration in the nude mouse xenograft model. Involvement.

Protease/anti-protease imbalance and oxidative stress are viable pro-inflammatory mechanisms that contribute to the pathogenesis of chronic obstructive.

Circulating serum inflammatory markers, a) neutrophils, b) platelets, c) fibrinogen and d) C-reactive protein (CRP), in patients with chronic airflow obstruction.

A) Axial and b) coronal computed tomography scans of usual interstitial pneumonia pattern in a patient with rheumatoid arthritis. a) Axial and b) coronal.

Platelets arrive at the scene of fibrosis……studies

Impaired Lung Function and Risk for Stroke

Compounds acting on pathogenic pathways of pulmonary arterial hypertension. Compounds acting on pathogenic pathways of pulmonary arterial hypertension.

Cellular players and molecules in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease. Cellular players and.

Pathogenic concepts of pulmonary arterial hypertension (PAH).

A representation of the key factors controlling host–environment interactions and influencing individual phenotypes and, therefore, susceptibility to disease.

Schematic of the relationship between smoking and legume consumption (smoking–diet relationship) in relation to pulmonary inflammation, systemic inflammation,

ACPA and RF titres in patients with early RA treated with abatacept+MTX compared with MTX alone. ACPA and RF titres in patients with early RA treated with.

Schematic diagram of the potential cellular effects of interleukin (IL)-4/IL-13 on inflammatory and structural cells in asthma. Schematic diagram of the.

High-resolution computed tomography images of smoking-related interstitial lung diseases (ILDs). a) Pulmonary Langerhans cell histiocytosis, b) respiratory.

Presentation transcript:

Schematic illustration of the concepts in the pathogenesis of rheumatoid arthritis associated-interstitial lung disease (RA-ILD). Schematic illustration of the concepts in the pathogenesis of rheumatoid arthritis associated-interstitial lung disease (RA-ILD). While the pathogenesis of RA-ILD is not fully understood, genetic predisposition and epigenetic factors are thought to play a role. Some patients with rheumatoid arthritis may have a genetic predisposition to ILD. Human leukocyte antigen (HLA)-B54, HLA-DQ1B*0601, HLA-B40, HLA-DR4 and the site encoding α-1 protease inhibitor have been associated with increased risk of ILD in rheumatoid arthritis, while some shared epitopes (HLA-DRB1) have been associated with the development of rheumatoid arthritis but decreased rates of RA-ILD. Male sex and older age are additional risk factors for RA-ILD. Both genetic factors and smoking are associated with increased citrullination of proteins in the lung, which allows for exposure of new epitopes and an autoimmune response. Higher levels of anti-cyclic citrullinated peptide (CCP) antibodies have been found in patients with RA-ILD compared to patients with rheumatoid arthritis only, but the role of such antibodies in the pathogenesis of RA-ILD is not clear. Smoking is also a risk factor for rheumatoid arthritis alone and results in repeated injuries to the alveolar epithelium and alterations in the cytokine milieu. As in other ILDs, the inflammatory response activates cytokines, chemokines and growth factors, such as tumor necrosis factor (TNF), vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and interleukins (IL). These contribute to a differentiation and proliferation of fibroblasts, increased synthesis and deposition of extracellular matrix (ECM) and increased activity of matrix metalloproteinases (MMP) resulting in ILD. Fibroblasts in the synovial lining play a similar role in the pathogenesis of joint manifestations of rheumatoid arthritis. (Figure prepared with assistance from Sean Mclaughlin; Seattle, WA, USA). Megan Shaw et al. Eur Respir Rev 2015;24:1-16 ©2015 by European Respiratory Society