The Journal of Allergy and Clinical Immunology: In Practice

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Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Long-term Quality of Life After Treatment of Laryngeal.

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Presentation transcript:

The Journal of Allergy and Clinical Immunology: In Practice Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma Claus Bachert, MD, PhD, Peter W. Hellings, MD, PhD, Joaquim Mullol, MD, PhD, Robert M. Naclerio, MD, Jingdong Chao, PhD, Nikhil Amin, MD, Annette Grabher, MD, MPH, Brian N. Swanson, PhD, Jennifer D. Hamilton, PhD, Sophie Guillonneau, MSc, Christine Taniou, Donghui Zhang, PhD, Gianluca Pirozzi, MD, PhD, Neil M.H. Graham, MB, BS, MD, MPH, Heribert Staudinger, MD, PhD, Leda P. Mannent, MD, Asif Khan, MB, BS, MPH The Journal of Allergy and Clinical Immunology: In Practice DOI: 10.1016/j.jaip.2019.03.023 Copyright © 2019 The Authors Terms and Conditions

Figure 1 Change in generic HRQoL outcomes: least-squares mean change from baseline in EQ-5D self-rated health VAS (mm) score at week 16 (A), and in SF-36 individual domain scores at week 16 (B). LS means (and corresponding P values) are based on the mixed-effects model with repeated measures. Blue asterisks indicate statistically significant improvement from baseline within dupilumab-treated patients (P < .05). Gray asterisks indicate statistically significant improvement from baseline within placebo-treated patients (P < .05). BP, Bodily pain; EQ-5D, 5-dimension EuroQoL questionnaire; GH, general health; HRQoL, health-related quality of life; MCS, mental component summary; MFNS, mometasone furoate nasal spray; MH, mental health; PCS, physical component summary; PF, physical functioning; RE, role-emotional; RP, role-physical; SE, standard error; SF, social functioning; SF-36, 36-item Short-Form Health Survey; VAS, visual analog scale; VT, vitality. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2019.03.023) Copyright © 2019 The Authors Terms and Conditions