1. SF-36 domain scores at baseline and 24 weeks compared with age-matched and gender-matched normative values in the (A) AMBITION and (B) ADACTA trial populations.
SF-36 domain scores at baseline and 24 weeks compared with age-matched and gender-matched normative values in the (A) AMBITION and (B) ADACTA trial populations. Analyses were performed using the per-protocol population in AMBITION (TCZ, n=265; MTX, n=259) and the intention-to-treat population in ADACTA (TCZ, n=163; ADA, n=162). Normative values were defined as age-matched and gender-matched scores in a non-RA population without comorbid conditions. AMBITION population: PF: ≥78.8; RP: ≥79.1; BP: ≥67.4; GH: ≥68.2; VT: ≥56.6; SF: ≥81.7; RE: ≥85.0; MH: ≥72.9. ADACTA population: PF: ≥78.3; RP: ≥79.0; BP: ≥68.1; GH: ≥69.3; VT: ≥58.3; SF: ≥83.4; RE: ≥86.3; MH: ≥75.1. ADA, adalimumab; BP, bodily pain; GH, general health; MH, mental health; MTX, methotrexate; PF, physical functioning; RA, rheumatoid arthritis; RE, role-emotional; RP, role-physical; SF, social functioning; SF-36, Short Form-36; TCZ, tocilizumab; VT, vitality.
Vibeke Strand et al. RMD Open 2017;3:e000496
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