Volume 54, Issue 5, Pages (November 1998)

Slides:

Advertisements

Similar presentations

Renal neuronal nitric oxide synthase protein expression as a marker of renal injury Attila J. Szabo, Laszlo Wagner, Aaron Erdely, Kim Lau, Chris Baylis.

Advertisements

From: Myeloperoxidase-associated Tyrosine Nitration after Intratracheal Administration of Lipopolysaccharide in Rats Anesthes. 2002;97(4): Figure.

Volume 59, Issue 5, Pages (May 2001)

Volume 68, Issue 4, Pages (October 2005)

Volume 59, Issue 3, Pages (March 2001)

Volume 73, Issue 11, Pages (June 2008)

Volume 69, Issue 6, Pages (March 2006)

Cyril H. Barton, Zehnmin Ni, Nosratola D. Vaziri Kidney International

George D. Webb, PhD, Lay Har Lim, BSc, Vernon M. S

Volume 62, Issue 6, Pages (December 2002)

Adenosine-induced apoptosis in glomerular mesangial cells

Volume 76, Issue 1, Pages (July 2009)

Volume 116, Issue 6, Pages (June 1999)

Mechanical stress reduces podocyte proliferation in vitro

Volume 56, Issue 6, Pages (December 1999)

Volume 72, Issue 4, Pages (August 2007)

Volume 58, Issue 1, Pages (July 2000)

C.B. Marshall, J.W. Pippin, R.D. Krofft, S.J. Shankland

Volume 55, Issue 6, Pages (June 1999)

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes Marcel B.M. Teunissen, Jan.

Volume 69, Issue 10, Pages (May 2006)

Volume 69, Issue 8, Pages (April 2006)

Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis Hua Liu, Radhakrishna Baliga Kidney International

Volume 59, Issue 3, Pages (March 2001)

Volume 128, Issue 5, Pages (May 2005)

Volume 59, Issue 5, Pages (May 2001)

PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3- kinase in mesangial cells Jian Yao, Tetsuo Morioka, Takashi Oite Kidney.

Volume 62, Issue 5, Pages (November 2002)

Karl A. Nath, Anthony J. Croatt, Jill J. Haggard, Joseph P. Grande

Volume 84, Issue 5, Pages (November 2013)

Role of meprin A in renal tubular epithelial cell injury

Fan Zhang, Yaw L. Siow, Karmin O Kidney International

Volume 68, Issue 4, Pages (October 2005)

Volume 65, Issue 3, Pages (March 2004)

Dominique A. Joly, Jean-Pierre Grünfeld Kidney International

Volume 83, Issue 3, Pages (March 2013)

Wei-Zhong Ying, Paul W. Sanders Kidney International

Volume 73, Issue 5, Pages (March 2008)

Janet D. Klein, Robert B. Gunn, Brian R. Roberts, Jeff M. Sands

Hai Tao Yuan, Su Ping Yang, Adrian Spencer Woolf Kidney International

Volume 61, Issue 1, Pages (January 2002)

Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells Gur P. Kaushal, Varsha Kaushal, Ph.D., Xiaoman.

Hongli Lin, Xiangmei Chen, Jianzhong Wang, Zhiheng Yu

Volume 58, Issue 6, Pages (December 2000)

Calcitonin receptor isoforms expressed in the developing rat kidney

Volume 75, Issue 5, Pages (March 2009)

Volume 74, Issue 6, Pages (September 2008)

Recruitment of renal tubular epithelial cells expressing verotoxin-1 (Stx1) receptors in HIV-1 transgenic mice with renal disease Xue-Hui Liu, Clifford.

Volume 62, Issue 4, Pages (October 2002)

Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy Udo Rolle, Hideki Shima, Prem Puri Kidney.

Volume 60, Issue 6, Pages (December 2001)

Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease Shen Xiao, Laszlo Wagner, Rebecca J. Schmidt,

Immunolocalization of phospholipase C isoforms in rat kidney

Volume 62, Issue 1, Pages (July 2002)

Volume 56, Issue 5, Pages (November 1999)

Prasun K. Datta, Elias A. Lianos Kidney International

H. Raffi, J.M. Bates, Z. Laszik, S. Kumar Kidney International

Expression of Opsin Molecule in Cultured Murine Melanocyte

Direct effects of dexamethasone on human podocytes

Cyril H. Barton, Zhemin Ni, Nosratola D. Vaziri Kidney International

Volume 56, Issue 6, Pages (December 1999)

Effects of mifepristone on expression of endothelial nitric oxide synthase in human endometrium during the implantation phase Xiaoxi Sun, M.D., Xiaoyan.

Volume 71, Issue 9, Pages (May 2007)

Volume 75, Issue 5, Pages (March 2009)

Volume 62, Issue 5, (November 2002)

Volume 58, Issue 6, Pages (December 2000)

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells Yuzhi Hong, Wuding Zhou, Ke Li,

Bismarck Amoah-Apraku, Mao-Zhong Fang, Nicolas J. Guzman, M.D

Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis Monica.

Eric N Haugen, Anthony J Croatt, Karl A. Nath Kidney International

Presentation transcript:

Volume 54, Issue 5, Pages 1520-1528 (November 1998) Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys Norman Bank, Militza Kiroycheva, Fayyaz Ahmed, Gillian M. Anthony, Mary E. Fabry, Ronald L. Nagel, Pravin C. Singhal Kidney International Volume 54, Issue 5, Pages 1520-1528 (November 1998) DOI: 10.1046/j.1523-1755.1998.00148.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Top: Densitometric quantification of tyrosine nitration of the 57 kD protein expressed as the ratio of the means compared to normal mice from 7 groups of 4 mice each.Bottom: Western blot of renal protein extracts using a monoclonal antibody directed against nitrotyrosine (exposure 1min). Lane 1, normal mouse; lane 2, hypoxic normal mouse; lane 3, sickle cell mouse; lane 4, hypoxic sickle cell mouse. Kidney International 1998 54, 1520-1528DOI: (10.1046/j.1523-1755.1998.00148.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Immunohistochemistry staining of nitrotyrosine in mouse renal medulla and papilla. (A) Normal mouse. (B) βS sickle cell mouse, negative control (Methods section). (C) βS sickle cell mouse renal medulla. (D) βS sickle cell mouse renal papilla. Kidney International 1998 54, 1520-1528DOI: (10.1046/j.1523-1755.1998.00148.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Paired immunohistochemistry staining of both inducible nitric oxide synthase (iNOS) and nitrotyrosine in individual kidneys of normal and βSsickle cell mice. Paired photomicrographs are from closely adjacent areas. Kidney International 1998 54, 1520-1528DOI: (10.1046/j.1523-1755.1998.00148.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Agarose gel electrophoresis of DNA extracted from renal cells. Lane 1, 123kb marker; lane 2, normal mouse; lane 3, sickle cell mouse; lane 4, hypoxic normal mouse; lane 5, hypoxic sickle cell mouse. Kidney International 1998 54, 1520-1528DOI: (10.1046/j.1523-1755.1998.00148.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Occurrence of apoptosis in mouse renal medulla detected by TUNEL method. TUNEL-positive cells are indicated by arrows. (A) Normal mouse. (B) Hypoxic normal mouse. (C) Sickle cell mouse. (D) Hypoxic sickle cell mouse. Kidney International 1998 54, 1520-1528DOI: (10.1046/j.1523-1755.1998.00148.x) Copyright © 1998 International Society of Nephrology Terms and Conditions