Aging reduces postischemic recovery of coronary endothelial function

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Presentation transcript:

Aging reduces postischemic recovery of coronary endothelial function Mohamed Amrani, MD, Adrian H. Chester, PhD, Jay Jayakumar, MB, Magdi H. Yacoub, FRCS The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 1, Pages 238-245 (January 1996) DOI: 10.1016/S0022-5223(96)70421-X Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Experimental time course. Analog tracing showing the sequence of perfusion and the variation of coronary flow (ml/L) before (A) and after (B) ischemia. K, Krebs solution. Triangle represents onset of cardioplegic arrest. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 238-245DOI: (10.1016/S0022-5223(96)70421-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 A, Influence of age on preischemic and postischemic responses to 5-HT and to l-NMMA. Each bar represents the mean of six hearts ± SEM. Between each age group, p < 0.05, and p < 0.05 between preischemic (hatched bars) and postischemic (black bars) values in each age group. B, Influence of age on postischemic recovery of coronary response to 5-HT (hatched bars) and to l-NMMA (black bars). Each bar represents the mean of six hearts ± SEM. Between each age group, p < 0.05, except between groups 1 and 4 (p < 0.02). CF, Coronary flow. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 238-245DOI: (10.1016/S0022-5223(96)70421-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 A, Influence of age on preischemic and postischemic responses to 5-HT and to l-NMMA. Each bar represents the mean of six hearts ± SEM. Between each age group, p < 0.05, and p < 0.05 between preischemic (hatched bars) and postischemic (black bars) values in each age group. B, Influence of age on postischemic recovery of coronary response to 5-HT (hatched bars) and to l-NMMA (black bars). Each bar represents the mean of six hearts ± SEM. Between each age group, p < 0.05, except between groups 1 and 4 (p < 0.02). CF, Coronary flow. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 238-245DOI: (10.1016/S0022-5223(96)70421-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 A. Effect of age on preischemic and postischemic coronary responses to GTN. Each bar represents the mean of six hearts ± SEM. Between each age group, p was not significant, and p was also not significant between preischemic (hatched bar) and postischemic (black bar) values in each age group. B, Effect of age on postischemic recovery of coronary response to GTN. Between each age group, p was not significant. CF, Coronary flow. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 238-245DOI: (10.1016/S0022-5223(96)70421-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 A. Effect of age on preischemic and postischemic coronary responses to GTN. Each bar represents the mean of six hearts ± SEM. Between each age group, p was not significant, and p was also not significant between preischemic (hatched bar) and postischemic (black bar) values in each age group. B, Effect of age on postischemic recovery of coronary response to GTN. Between each age group, p was not significant. CF, Coronary flow. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 238-245DOI: (10.1016/S0022-5223(96)70421-X) Copyright © 1996 Mosby, Inc. Terms and Conditions