MEMORY A journey from the mind to the molecules -Mr. Arjun Maitra -Assistant Professor Dept. of Physiology PCMS&RC.

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Presentation transcript:

MEMORY A journey from the mind to the molecules -Mr. Arjun Maitra -Assistant Professor Dept. of Physiology PCMS&RC

TO MY STUDENTS HERE I HAVE TRIED TO SIMPLIFY THE HUGE SUBJECT WITH ANIMATIONS, DIAGRAMS, FLOW CHARTS & RELEVENT MCQs. DIFFERENT TEXT BOOKS AND REFERENCE BOOKS HAVE BEEN USED FOR PREPARING THE CONTENTS. SLIDES ARE NOT THE SUBSTITUTE REMEMBERTHESE SLIDES ARE NOT THE SUBSTITUTE OF YOUR TEXT BOOKS ANIMATIONS AND DIAGRAMS ARE COLLECTED FROM DIFFERENT WEBSITE SOLELY FOR EDUCATION PURPOSE.

Eric. R. Kandel (MD) Nobel Prize :2000 (Physiology) Nobel Lecture: The Molecular Biology of Memory Storage: A Dialog between Genes and Synapses

In the Beginning there was... Memory But it soon became apparent that not all memory was created equal… Whats your mothers name? What did you have for lunch today? Yesterday? Two days ago? What color is the car youre parked next to? How do you ride a bike?

Memory sensoryshort termlong term working iconicechoic phonol. loop v-s sketch pad Central Exec phon. storerehearsal declarative (explicit) non-decl. (implicit) factsevents skills habits priming class. cond....

HOW MEMORY IS BUILT:::::::::::::: APLANFORAAPLANFORA LAYMANLAYMAN

AREAS OF BRAIN ASSOCIATED WITH MEMORY

WHERE IS THE HARD DISK HIDDEN IN THE BRAIN

WHERE WAS THE ELEPHANT HIDING IN SIDE BRAIN ELEPHANT LEFT MEDIAL TEMPORAL LOBE VISUAL CUES OCCIPITAL LOBE AND SURROUNDIG AREA RECOGNITION LEFT OCCIPITO TEMPORAL CORTEX NAMING LEFT MEDIAL TEMPORAL LOBE HAMMER INSIDE THE HEAD HAMMER POSTERIOR PARIETAL CORTEX NAMING LEFT PREMOTOR AREA + LEFT MIDDLE TEMPORAL GYRUS

HIPPOCAMPAL FORMATION & PATHWAYS

HOW DO WE RECOGNISES FACES

OCCIPITAL CORTEX VISUAL ASSOCIATION AREA INFEROTEMPORAL CORTEX MESO TEMPORAL ASSOCIATION CORTEX PARA HIPPOCAMPAL CORTEX PERIHINAL CORTEX ENTORHINAL CORTEX PERFORANT PATHWAY HIPPOCAMPUS MEDIAL TEMPORAL LOBE HOW MEMORY FOR A FACE IS REGISTERED

NOW HOW THE MEMORY IS RETRIEVED IN TERMS OF NEURAL NETWORK

entorhinal cortex perforant path dentate gyrus mossy fibres CA3 Schaffer collaterals (and a big projection via the fimbria to the contralateral hippocampus) CA1 alveus entorhinal cortex

SOME GENES RELATED TO MEMORY HCN 1 zif268 c-fos arc Homer

NOW THINK BEFORE YOU START REMEMBERING A FEW THINGS FROM THIS SEMINAR

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