1. The Trisynaptic Neuronal Network Of The Hippocampus.
Created By: Alex Szendrei

2. The Hippocampus Part of the limbic system
Memory and spatial navigation
Located in the medial temporal lobe, underneath the cortical surface
Two halves: left and right sides of the brain
Resembles a seahorse, "hippo- kampos"

3. Parts Of Hippocampus Dentate gyrus (DG) Hippocampus proper:
CA1–3 (cornu ammonis)
Subicular complex:
Subiculum (sb)
Presubiculum (prs)
Parasubiculum (pas)
Entorhinal cortex (EC):
Medial (MEC)
Lateral (LEC)

4. Trisynaptic Circuit
In transverse plane, three interconnected afferent pathways
Three major cell groups: granule cells, CA3 pyramidal neurons, and CA1 pyramidal cells.
Trisynaptic pathway
Entorhinal cortex -> the dentate gyrus
Dentate gyrus -> CA3 via mossy cell fibers.
Ca3 -> ca1 via schaffer collaterals
Ca1 -> sbiculum, carried out through the fornix.
Collectively the dentate gyrus, ca1 and ca3 of the hippocampus compose the trisynaptic loop.

5. Thank you for your attention.
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