Lung Transplantation in Gaucher Disease Geertje M. de Boer, BSc, Laura van Dussen, MD, PhD, Leon M. van den Toorn, MD, PhD, Michael A. den Bakker, MD, PhD, Rogier A.S. Hoek, MD, Dennis A. Hesselink, MD, PhD, Carla E.M. Hollak, MD, PhD, Peter Th. W. van Hal, MD, PhD  CHEST  Volume 149, Issue 1, Pages e1-e5 (January 2016) DOI: 10.1016/j.chest.2015.09.011 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 Pulmonary tissue, (hematoxylin and eosin stain, original magnification ×10) from the explanted lungs from the patient in our study with Gaucher disease and severe pulmonary hypertension. There are vascular changes with intimal thickening and medial hypertrophy of small centrilobular pulmonary arteries consistent with pulmonary hypertension. The insert (hematoxylin and eosin stain, original magnification ×40) shows a cluster of Gaucher cells in the pulmonary alveolar interstitium. CHEST 2016 149, e1-e5DOI: (10.1016/j.chest.2015.09.011) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 Estimated glomerular filtration (eGFR) rates pretransplantation and posttransplantation. The time scale and renal function are given on the abscissa and ordinate, respectively. The declining eGFR improved initially after lung transplantation (arrow 1), although a gradual decrease was noticed a few months later. After kidney transplantation (arrow 2), eGFR improved significantly. CHEST 2016 149, e1-e5DOI: (10.1016/j.chest.2015.09.011) Copyright © 2016 American College of Chest Physicians Terms and Conditions