CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment Dianne F. Newbury, Laura Winchester, Laura Addis, Silvia Paracchini, Lyn-Louise.

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CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment Dianne F. Newbury, Laura Winchester, Laura Addis, Silvia Paracchini, Lyn-Louise Buckingham, Ann Clark, Wendy Cohen, Hilary Cowie, Katharina Dworzynski, Andrea Everitt, Ian M. Goodyer, Elizabeth Hennessy, A. David Kindley, Laura L. Miller, Jamal Nasir, Anne O'Hare, Duncan Shaw, Zoe Simkin, Emily Simonoff, Vicky Slonims, Jocelynne Watson, Jiannis Ragoussis, Simon E. Fisher, Jonathon R. Seckl, Peter J. Helms, Patrick F. Bolton, Andrew Pickles, Gina Conti-Ramsden, Gillian Baird, Dorothy V.M. Bishop, Anthony P. Monaco The American Journal of Human Genetics Volume 85, Issue 2, Pages 264-272 (August 2009) DOI: 10.1016/j.ajhg.2009.07.004 Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 1 Association in SLIC Cohort Association results for family-based quantitaive analysis and case-control analysis of nonword repetition across the SLI1 region. In the case-control analysis, cases and controls were selected on the basis of their nonword-repetition performance (see text). Gaps in data represent regions where there are no mapped genes. SNPS included in the screen genotype panel are shown as +, and SNPs included in the follow-up genotype panel are shown as x. The American Journal of Human Genetics 2009 85, 264-272DOI: (10.1016/j.ajhg.2009.07.004) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 2 Nonword-Repetition Means for CMIP and ATP2C2 in SLIC and Replication Cohorts (A) CMIP. (B) ATP2C2. All means are for age- and sex-adjusted nonword-repetition scores standardized with a mean of 0 and a SD of 1. The three CMIP SNPs (rs12927866, rs4265801, and rs16955705) show genotype trends in the opposite direction from SLIC (A), whereas the three ATP2C2 SNPs (rs16973771, rs2875891, and rs8045507) show genotype trends in the same direction as SLIC (B). The American Journal of Human Genetics 2009 85, 264-272DOI: (10.1016/j.ajhg.2009.07.004) Copyright © 2009 The American Society of Human Genetics Terms and Conditions