Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Slides:

Advertisements

Similar presentations

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Advertisements

Manuel J. Antunes, MD, PhD, DSc

Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts Sidney Chocron, MDa, Kifah Alwan, MDa, Gerard Toubin, MDb,

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel

Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.

Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,

Thrombosis of the pulmonary artery stump after distal ligation

B. Albat, MD, P. Messner-Pellenc, MD, A. Thévenet, MD

Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,

Klaus Langes, MD, Dietmar Koschyk, MD, Detlef G. Mathey, MD

Amine Mazine, MD, MSc, Subodh Verma, MD, PhD, Bobby Yanagawa, MD, PhD

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Juan A. Crestanello, MD, Richard C. Daly, MD

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Daniel R. Meldrum, MD, Joseph C. Cleveland, MD, Brett C

Implantation of a left ventricular assist device, back-to-front, in an adolescent with a failing mustard procedure Lars Wiklund, MD, PhD, Sveneric Svensson,

Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and NA+/K+/2CL- cotransport inhibition on extracellular potassium accumulation.

Shigeyuki Sasaki, MD, PhD (by invitation), James D

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Expanding left ventricular assist device use to patients with disabilities: The role of assistive technology Juan A. Crestanello, MD The Journal of.

Editorial: The core of leadership

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart.

Physiologic Effects Of Extracellular Superoxide Dismutase Transgene Overexpression On Myocardial Function After Ischemia And Reperfusion Injury Edward.

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Cardiac myocyte functional and biochemical changes after hypothermic preservation in vitro Hiroyuki Orita, MD, Manabu Fukasawa, MD, Shigeki Hirooka,

Juan N. Pulido, MD The Journal of Thoracic and Cardiovascular Surgery

Transvenous versus transthoracic cardioverter-defibrillator implantation: A comparative analysis of morbidity, mortality, and survival David M. Shahian,

Support Your Specialty

Quality of mitral valve surgery at the United States Department of Veterans Affairs Juan A. Crestanello, MD The Journal of Thoracic and Cardiovascular.

Postinfarction ventricular septal rupture: Repair by endocardial patch with infarct exclusion Tirone E. David, MD, Laura Dale, RN (by invitation), Zhao.

Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy

Cardioplegia and vascular injury

Modified Ultrafiltration Versus Conventional Ultrafiltration: A Randomized Prospective Study In Neonatal Piglets C.William Daggett, MD, Andrew J. Lodge,

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Commentary: Faster recovery after complex neonatal cardiac surgery

Metabolic and hemodynamic effects of intravenous glutamate infusion early after coronary operations Rolf Svedjeholm, MD, PhDa, Ingemar Vanhanen, MDa,

The diabetes epidemic and its effect on cardiac surgery practice

Leora B. Balsam, MD, Abe DeAnda, MD

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Desensitization of myocardial β-adrenergic receptors and deterioration of left ventricular function after brain death Thomas A. D'Amico, MDa, Cary H.

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Myocardial stunning: A therapeutic conundrum

P.K. Spanos, MD, A.D. Bisbos, MD, I.I. Arditis, MD

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Severe tricuspid or mitral regurgitation in inoperable patients with aortic stenosis. Can we leave them alone? Juan A. Crestanello, MD The Journal of.

The future of cardiac surgery training: A survival guide

Commentary: Doing what is right—We are all in this together

Seeing is believing: A call for routine early postoperative hemodynamic transesophageal echocardiography monitoring after left ventricular assist device.

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

Myocardial protection by ischemic preconditioning and δ-opioid receptor activation in the isolated working rat heart Matthias Karck, MDa, Satonori Tanaka,

Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings? Chadrick E. Denlinger, MD The Journal.

First in line for robotic surgery: Would you want to know?

Commentary: Just say NO

Minimally invasive direct coronary artery bypass, percutaneous transluminal coronary angioplasty, and stent placement for left main stenosis William.

Echo-free perfused spaces: A current postoperative finding after homograft replacement of the aortic valve T. Carrel, MD, M. Pasic, MD, E. Oechslin,

Gastrointestinal bleeding after left ventricular assist device implantation: It is all about the platelets Juan A. Crestanello, MD The Journal of Thoracic.

The Impact of New Technology on Cardiothoracic Surgical Practice

Peter B. Manning, MD§, John E. Mayer, MD, Gil Wernovsky, MD§, Steven B

Journal changes and initiatives

Calpain inhibitors: The aspirin of the 21st century?

Presentation transcript:

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD (by invitation), Joseph Kamelgard, MD (by invitation), David M. Lingle, MD (by invitation), Svend A. Mortensen, MD (by invitation), Morten Rhode, (by invitation), Glenn J.R. Whitman, MD The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 2, Pages 443-450 (February 1996) DOI: 10.1016/S0022-5223(96)70455-5 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Recovery of mechanical function during reperfusion expressed as a percentage of end-equilibration left ventricular DP. Asterisk indicates p < 0.005 versus control. Note improvement afforded by CoQ10 pretreatment. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 443-450DOI: (10.1016/S0022-5223(96)70455-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 DP/MVo2 during equilibration and at end-reperfusion. During reperfusion CoQ10 hearts maintained their preischemic efficiency, in contrast to control hearts. Asterisk indicates p < 0.05 versus CoQ10 group at reperfusion and vs both groups at equilibration. V, Ventricle. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 443-450DOI: (10.1016/S0022-5223(96)70455-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Myocardial CK activity at end-equilibration and at end-reperfusion. Hearts pretreated with CoQ10 maintained greater CK activity than did control hearts. Asterisk indicates p < 0.05 versus control at reperfusion. V, Ventricle. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 443-450DOI: (10.1016/S0022-5223(96)70455-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Phosphocreatine (PCr) levels during equilibration (EQ) and during reperfusion (RP). CoQ10 hearts showed higher levels during both equilibration and reperfusion. Asterisk indicates p < 0.005 versus control. Horizontal axis indicates time in minutes. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 443-450DOI: (10.1016/S0022-5223(96)70455-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 ATP levels during equilibration (EQ) and during reperfusion (RP). CoQ10 hearts showed higher levels during both equilibration and reperfusion. Asterisk indicates p < 0.05 versus control. Horizontal axis indicates time in minutes. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 443-450DOI: (10.1016/S0022-5223(96)70455-5) Copyright © 1996 Mosby, Inc. Terms and Conditions