S. Seshadri, S.K. Sunkara, Y. Khalaf, T. El-Toukhy, H. Hamoda

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Presentation transcript:

Effect of heparin on the outcome of IVF treatment: a systematic review and meta- analysis S. Seshadri, S.K. Sunkara, Y. Khalaf, T. El-Toukhy, H. Hamoda Reproductive BioMedicine Online Volume 25, Issue 6, Pages 572-584 (December 2012) DOI: 10.1016/j.rbmo.2012.08.007 Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 The PRISMA flow diagram. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Funnel plot to assess publication and related biases in the systematic review of heparin in IVF cycles for the outcome of clinical pregnancy. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 The effect of heparin versus placebo on the live birth rate (randomized controlled trials). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 The effect of heparin versus placebo on the live birth rate (observational studies). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 5 The effect of heparin versus placebo on the live birth rate in women with recurrent implantation failure without coagulation defects. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 6 The effect of heparin versus placebo on the clinical pregnancy rate (randomized controlled trials). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 7 The effect of heparin versus placebo on the clinical pregnancy rate (observational studies). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 8 The effect of heparin versus placebo on the clinical pregnancy rate in women with recurrent implantation failure without coagulation defects. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 9 The effect of heparin versus placebo on the implantation rate (randomized controlled trials). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 10 The effect of heparin versus placebo on the implantation rate (observational studies). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 11 The effect of heparin versus placebo on the implantation rate in women with recurrent implantation failure without coagulation defects. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 12 The effect of heparin versus placebo on the miscarriage rate (randomized controlled trials). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 13 The effect of heparin versus placebo on the miscarriage rate (observational studies). Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 14 The effect of heparin versus placebo on the miscarriage rate in women with recurrent implantation failure without coagulation defects. Reproductive BioMedicine Online 2012 25, 572-584DOI: (10.1016/j.rbmo.2012.08.007) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions