TNF-α Gene Promoter -238G>A and -308G>A Polymorphisms Alter Risk of Psoriasis Vulgaris: A Meta-Analysis  Chunying Li, Gang Wang, Ying Gao, Ling Liu, Tianwen Gao  Journal of Investigative Dermatology  Volume 127, Issue 8, Pages 1886-1892 (August 2007) DOI: 10.1038/sj.jid.5700822 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 ORs (log scale) of psoriasis associated with TNF-α –238G>A for the AA+AG genotype compared with the GG genotype. For each study, the estimate of OR and its 95% CI is plotted with a box and a horizontal line. ♦, pooled OR and its 95% CI. (a) Stratified by ethnicity. (b) Stratified by type of the psoriasis. Journal of Investigative Dermatology 2007 127, 1886-1892DOI: (10.1038/sj.jid.5700822) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 ORs (log scale) of psoriasis associated with TNF-α –308G>A or the AA+AG genotype compared with the GG genotype. For each study, the estimate of OR and its 95% CI is plotted with a box and a horizontal line. ♦, pooled OR and its 95% CI. (a) Stratified by ethnicity. (b) Stratified by type of the psoriasis. Journal of Investigative Dermatology 2007 127, 1886-1892DOI: (10.1038/sj.jid.5700822) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Funnel plot analysis to detect publication bias. Each point represents a separate study for the indicated association. For each study, the OR is plotted on a logarithmic scale against the precision (the reciprocal of the SE). If bias is absent, small studies will have ORs that are widely scattered but still centered around the OR estimates provided by large, more precise studies. (a) For TNF-α –238G>A polymorphism. (b) For TNF-α –308G>A polymorphism. Journal of Investigative Dermatology 2007 127, 1886-1892DOI: (10.1038/sj.jid.5700822) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions